Mounjaro and A1C: How Much It Lowers Blood Sugar
In SURPASS-2, A1C fell by 2.3 points on tirzepatide 15 mg weekly, in adults with type 2 diabetes on metformin.
- Biggest A1C drop
- 2.3 points
- Trial
- SURPASS-2
Mounjaro: key facts
Its half-life is about 5 days. After 5 days, half is gone, while about 3% remains after five half-lives (25 days).
For type 2 diabetes, SURPASS-1 showed 7.8 kg of weight loss over 40 weeks, while placebo showed 1 kg.
Monthly prices in US dollars include list prices and self-pay offers. Each figure comes from the maker's pricing page.
Sources: FDA label (DailyMed), healthsystemtracker.org, pricinginfo.lilly.com.
A1C results in the trials by dose
| Trial | Dose group | A1C change | Placebo or comparison | Weeks | Who was in it |
|---|---|---|---|---|---|
| SURPASS-2 | Tirzepatide 5 mg weekly | 2.01 points lower | semaglutide 1 mg (Ozempic) | 40 | Adults with type 2 diabetes on metformin |
| SURPASS-2 | Tirzepatide 10 mg weekly | 2.24 points lower | semaglutide 1 mg (Ozempic) | 40 | Adults with type 2 diabetes on metformin |
| SURPASS-2 | Tirzepatide 15 mg weekly | 2.3 points lower | semaglutide 1 mg (Ozempic) | 40 | Adults with type 2 diabetes on metformin |
| SURPASS-1 | Tirzepatide 5 mg weekly | 1.87 points lower | Not listed | 40 | These adults had type 2 diabetes and followed only diet and exercise |
| SURPASS-1 | Tirzepatide 10 mg weekly | 1.89 points lower | Not listed | 40 | These adults had type 2 diabetes and followed only diet and exercise |
| SURPASS-1 | Tirzepatide 15 mg weekly | 2.07 points lower | Not listed | 40 | These adults had type 2 diabetes and followed only diet and exercise |
Sources: SURPASS-2 (PubMed), SURPASS-1 (PubMed).
Source: FDA label (DailyMed).