GLP-1 Headaches: Causes, Duration, Migraine Link, What Helps
Yes. Headache is listed in 5 of 10 GLP-1 labels. The highest rate in each label runs from 9% on Foundayo to 14% on Wegovy. Placebo in the Wegovy trials: 10%.
- Labels that list it
- 5 of 10
- Highest rate
- 14% Wegovy
- Lowest rate
- 9% Foundayo
Weight loss and half-life at a glance
Half-life in days shows how long your body needs to clear half a dose. Section 12.3 of each FDA label provides this figure.
Body weight, as a percentage. For each one, read the result against its own placebo on its page. Trials, doses, and lengths differ.
How often it shows up: GLP-1 vs placebo
Wherever labels report it, they list GLP-1 headache. The highest dose group comes first. The trials covered by each label involved different groups of people. Think of it as a rough guide.
The table lists the pill forms too: Foundayo.
| Medicine | Highest rate in the label | Dose group | Placebo | People in the trials |
|---|---|---|---|---|
 Wegovy | 14% | 2.4 mg | 10% | Adults with obesity or overweight (weight management) |
 Saxenda | 13.6% | all doses | 12.6% | Adults with obesity or overweight (weight management) |
 Victoza | 11% | 1.2 mg | 7% | Adults with type 2 diabetes |
 Foundayo | 9% | 9 mg | 7% | Adults with obesity or overweight (weight management) |
| Byetta | 9% | all doses | 6% | Adults with type 2 diabetes |
 Ozempic | Not listed | – | – | – |
 Rybelsus | Not listed | – | – | – |
 Mounjaro | Not listed | – | – | – |
 Zepbound | Not listed | – | – | – |
 Trulicity | Not listed | – | – | – |
Sources: Wegovy label (DailyMed), Foundayo label (DailyMed), Saxenda label (DailyMed), Victoza label (DailyMed), Byetta label (DailyMed).
Source: DailyMed FDA label.
What the Byetta label states
Headache appears in the label in these exact words:
“Two of the 155 patients treated with BYETTA withdrew due to adverse reactions of headache and nausea.”
Source: DailyMed FDA label.