Tirzepatide and Wellbutrin: Is It Safe? Label, Studies
No interaction is listed; ask your pharmacist, since GLP-1 medicines can change how pills absorb.
- Verdict
- Ask your prescriber first
- Label names it
- 0 of 2
- General caution
- Pills absorbed more slowly
Check a GLP-1 interaction
Zepbound in brief
With a 5 to 6 day half-life, the amount drops by half after 5.5 d. About 3% remains after five half-lives (27.5 d).
In SURMOUNT-1 over 72 weeks, 20.9% of body weight was lost, compared with 3.1% on placebo.
The maker's price page lists monthly list prices and self-pay offers in US dollars.
Sources: FDA label (DailyMed), Eli Lilly 1 2, cnbc.com.
Tirzepatide and Wellbutrin: the verdict
Ask your prescriber first
The Mounjaro label uses these exact words in its drug interactions section:
“MOUNJARO delays gastric emptying and thereby has the potential to impact the absorption of concomitantly administered oral medications. Caution should be exercised when oral medications”
The source is the FDA DailyMed label.
Tirzepatide label details
The Mounjaro label does not include Wellbutrin (bupropion). These label statements still apply to it.
| Named in the label | The risk | What the label tells doctors |
|---|---|---|
| Oral medicines | Pills absorbed differently | Slowing stomach emptying may change how other pills are absorbed. |
Taken from the Mounjaro label (DailyMed).
What the studies show
- In the Drug Interactions label section,
- oral medicines label interaction
- a seizure risk factor if diabetes is treated with insulin or pills:
The source is the FDA DailyMed label.
The practical rule
- Inform both prescribers that you take the other medicine. Do not adjust either dose on your own.
- Tell your GLP-1 prescriber about every pill you take, including this one.
- Ask your pharmacist if any of your pills need to stay at a steady blood level. They may need a check when you start or increase the dose.
The source is the FDA DailyMed label.
Wellbutrin with other GLP-1s
None of the 10 GLP-1 labels list Wellbutrin (bupropion) in their drug interaction section. For every drug in this class, the general caution is the same for pills you swallow, so the answer does not change across the class.
That question applies in the same way to Ozempic, Wegovy, Mounjaro, Zepbound.
The source is the FDA DailyMed label.