GLP-1 and Jardiance: Is It Safe? Label, Studies
Often prescribed together; take extra care with fluids and meals when you are sick or eating little.
- Verdict
- Fine with care
- Label names it
- 0 of 10
- General caution
- Pills absorbed more slowly
Check a GLP-1 interaction
Weight loss and half-life, briefly
According to section 12.3 in each FDA label, half-life in days shows how long the body needs to clear half a dose.
Percentage of body weight. Trials vary in design, dose, and duration, so compare each result with the placebo result listed on that drug’s page.
GLP-1 and Jardiance: the verdict
Fine with care
The Ozempic label uses these exact words in its drug interactions section:
“OZEMPIC causes a delay of gastric emptying, and thereby has the potential to impact the absorption of concomitantly administered oral medications. In clinical pharmacology trials,”
Source: FDA DailyMed label.
What the GLP-1 label says
The Ozempic label does not name Jardiance (empagliflozin). Those statements still apply to it.
| Named in the label | The risk | What the label tells doctors |
|---|---|---|
| Insulin or sulfonylureas | Low blood sugar | Combining this medicine with insulin or a sulfonylurea, such as glipizide or glimepiride, raises the risk of low blood sugar. |
| Oral medicines | Pills absorbed differently | It slows how quickly your stomach empties. This can change how your body absorbs other pills. |
This comes from the Ozempic label (DailyMed).
What the studies show
- clinical trials: when used with SGLT2 inhibitors
- Warning in the label: Acute Kidney Injury Due to Volume Depletion
- a ketoacidosis trigger: reduced caloric intake
- ketoacidosis trigger: volume depletion
Source: FDA DailyMed label.
The practical rule
- Call your doctor that day if you cannot keep food or fluids down.
- Tell the prescriber of your GLP-1 about every pill you use, and mention this one too.
- Check with your pharmacist about whether the pills you take need steady blood levels. Checks may be needed when treatment starts or when the dose goes up.
- In the first weeks, monitor your blood sugar more often.
Source: FDA DailyMed label.
Jardiance with other GLP-1s
None of the 10 GLP-1 labels names Jardiance (empagliflozin) in the drug interaction section. All have the same general warning for pills you swallow. The answer is the same for this whole class.
The same question applies as well to Ozempic, Rybelsus, Mounjaro, Trulicity, Victoza.
Source: FDA DailyMed label.