Trulicity and Jardiance: Is It Safe? Label, Studies
Often prescribed together; take extra care with fluids and meals when you are sick or eating little.
- Verdict
- Fine with care
- Label names it
- No
- General caution
- Pills absorbed more slowly
Check a GLP-1 interaction
Trulicity in brief
Its half-life is about 5 days. After 5 d, half is gone. About 3% remains after five half-lives (25 d).
Sources: FDA label (DailyMed).
Trulicity and Jardiance: the verdict
Fine with care
These words come directly from the drug interactions section of the Trulicity label:
“TRULICITY delays gastric emptying and thus has the potential to reduce the rate of absorption of concomitantly administered oral medications. The delay in gastric emptying”
Source: FDA label (DailyMed)
The Trulicity label says
The Trulicity label does not name Jardiance (empagliflozin). These lines still apply to Jardiance.
| Named in the label | The risk | What the label tells doctors |
|---|---|---|
| Insulin or sulfonylureas | Low blood sugar | If you combine it with insulin or a sulfonylurea, including glipizide or glimepiride, the chance of low blood sugar increases. Your doctor may adjust those doses down. |
| Oral medicines | Pills absorbed differently | It slows stomach emptying, which can change how your body absorbs other pills. |
From the Trulicity label (DailyMed)
What the studies show
- clinical trial use with SGLT2 inhibitors
- Warning in the label concerning Acute Kidney Injury Due to Volume Depletion
- reduced caloric intake can trigger ketoacidosis
- Volume depletion can trigger ketoacidosis
Source: FDA label (DailyMed)
How the rule works in practice
- Food or fluids that will not stay down require a call to your doctor that same day.
- Tell whoever prescribes your GLP-1 about every pill you take, including this one.
- Have your pharmacist check whether any of your pills need to maintain a steady blood level. Starting the medicine or raising the dose may require a check of these pills.
- Check your blood sugar more often in the first weeks and following each dose increase.
Source: FDA label (DailyMed)
Jardiance with other GLP-1s
None of the 10 GLP-1 labels mentions Jardiance (empagliflozin) in their drug interaction sections. Each label gives the same general caution about pills you swallow, so the answer stays the same for this drug class.
The question remains the same for Ozempic, Rybelsus, Mounjaro, Victoza.
Source: FDA label (DailyMed)