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GLP-1 Decoder

Mounjaro and Birth Control: Is It Safe? Label, Studies

Mounjaro can make birth control pills less reliable for a while; add a backup method.

Verdict
Fine with care
Label says
Listed interaction

Check a GLP-1 interaction

Mounjaro facts at a glance

How long it remains in your body
100%50%25%0%05 d10 d15 d20 d25 d50%25%12.5%time after the dose

Its half-life is about 5 days. Half has cleared by 5 d, and roughly 3% remains after five half-lives (25 d).

Amount of weight lost during its main trial
Mounjaro (SURPASS-1)7.8 kgPlacebo1 kg

In SURPASS-1, people with type 2 diabetes lost 7.8 kg over 40 weeks, compared with 1 kg on placebo.

Cost over time
2026$1,112.16$0List priceSelf-pay

Monthly costs in US dollars include list price and self-pay offers. Each price comes from the maker's price page.

Sources: FDA label (DailyMed), healthsystemtracker.org, pricinginfo.lilly.com.

Mounjaro and birth control: the verdict

Fine with care

Word for word, from the drug interactions section of the Mounjaro label:

“Advise patients using oral hormonal contraceptives to switch to a non-oral contraceptive method or add a barrier method of contraception for 4 weeks after initiation”

This comes from the FDA label (DailyMed).

What the Mounjaro label says

Birth control pills are the subject of these Mounjaro label statements.

Drug interactions in the Mounjaro label
Named in the labelThe riskWhat the label tells doctors
Oral medicinesPills absorbed differentlyThis medicine slows how quickly your stomach empties, which may change how other pills are absorbed.
Birth control pillsBirth control pills may work less wellFor a while, this drug may make birth control pills less effective. Once you start it and every time the dose goes up, add a barrier method to your pills or use a non-oral method.

This comes from the Mounjaro label (DailyMed).

What the studies show

This comes from the FDA label (DailyMed).

The practical rule

After starting, and following every dose increase, use a non-pill method or add condoms for 4 weeks.

This comes from the FDA label (DailyMed).

Birth control with other GLP-1s

Each label's drug interaction section was reviewed for this same concern.

Birth control pills compared across GLP-1 labels
MedicineBirth control pills in the labelVerdictPage
OzempicNot named; general pill cautionGenerally fine togetherRead the answer
WegovyNot named; general pill cautionGenerally fine togetherRead the answer
RybelsusNot named; general pill cautionNot listedNot listed
MounjaroNamed in the labelFine with careNot listed
ZepboundNamed in the labelFine with careRead the answer
FoundayoNamed in the labelNot listedNot listed
TrulicityNot named; general pill cautionNot listedNot listed
SaxendaNot named; general pill cautionNot listedNot listed
VictozaNot named; general pill cautionNot listedNot listed
ByettaNamed in the labelNot listedNot listed

This comes from the FDA label (DailyMed).