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Wegovy Weight Gain: How Common, How Long It Lasts

The Wegovy label does not include weight gain as a side effect. What people mean by it: putting weight back on, most often after stopping the medicine.

In the label
Not listed
Most common in the label
Nausea 44%

Wegovy in brief

How long it remains in your body
100%50%25%0%07 d14 d21 d28 d35 d50%25%12.5%time after the dose

Its half-life is about 1 week. After 7 d, half is gone, and after five half-lives (35 d), about 3% remains.

Weight lost during its main trial
Wegovy (STEP 1)14.9%Placebo2.4%

In STEP 1 over 68 weeks, people lost 14.9% of body weight, compared with 2.4% on placebo.

Price over time
202520262027$1,349.02$0List priceSelf-pay

In US dollars, monthly price points are the list price and self-pay offers. The maker's price page supplies every figure.

Sources: FDA label (DailyMed), healthsystemtracker.org, prnewswire.com 1 2.

What the Wegovy label lists instead

The Wegovy label does not include weight gain. These five side effects appear most often on the label.

Table 3. Adults with Obesity or Overweight for Weight Reduction given WEGOVY 2.4 mg by injection: Adverse Reactions at 2% or more and Greater Than Placebo
Side effectPlaceboWegovy 2.4 mgMore than placebo
Nausea16%44%+28 points
Diarrhea16%30%+14 points
Vomiting6%24%+18 points
Constipation11%24%+13 points
Abdominal Pain10%20%+10 points

Source: Wegovy label (DailyMed).

The source is the FDA label on DailyMed.