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GLP-1 Decoder

Trulicity Weight Gain: How Common, How Long It Lasts

The Trulicity label does not include weight gain as a side effect. What people mean by it: putting weight back on, most often after stopping the medicine.

In the label
Not listed
Most common in the label
Nausea 21.1%

Key facts about Trulicity

How long it remains in the body
100%50%25%0%05 d10 d15 d20 d25 d50%25%12.5%time after the dose

Its half-life is about 5 days. After 5 d, half is gone, and about 3% remains after five half-lives (25 d).

Sources: FDA label (DailyMed).

Instead, the Trulicity label lists

The Trulicity label does not include weight gain. It does list five side effects that occur most often.

Table 1: Adverse Reactions found in the Pool of Placebo-Controlled Trials That Occurred in ≥5% of TRULICITY-Treated Adult Patients with Type 2 Diabetes Mellitus
Side effectPlaceboTrulicity 0.75 mgTrulicity 1.5 mgMore than placebo, 1.5 mg
Nausea5.3%12.4%21.1%+15.8 points
Vomiting2.3%6%12.7%+10.4 points
Diarrhea6.7%8.9%12.6%+5.9 points
Abdominal Pain4.9%6.5%9.4%+4.5 points
Decreased Appetite1.6%4.9%8.6%+7 points

Source: Trulicity label (DailyMed).

Source: FDA label (DailyMed).