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GLP-1 Decoder

Ozempic Weight Gain: How Common, How Long It Lasts

No weight gain entry appears on the Ozempic label as a side effect. What people mean by it: putting weight back on, most often after stopping the medicine.

In the label
Not listed
Most common in the label
Nausea 20.3%

Ozempic overview

How long it stays in the body
100%50%25%0%07 d14 d21 d28 d35 d50%25%12.5%time after the dose

Its half-life is about 1 week: after 7 d, half is gone, and after five half-lives (35 d), about 3% remains.

Weight lost in its main trial
Ozempic (SUSTAIN 1)4.7 kgPlacebo1.2 kg

In SUSTAIN 1, people with type 2 diabetes lost 4.7 kg over 30 weeks, compared with placebo at 1.2 kg.

Cost over time
202520262027$1,027.51$0List priceSelf-pay

Monthly amounts in US dollars include the list price and self-pay offers. Each comes from the maker's price page.

Sources: FDA label (DailyMed), healthsystemtracker.org, prnewswire.com 1 2.

What appears on the Ozempic label instead

No weight gain entry appears on the Ozempic label. It most often lists these five side effects.

Table 1. Adverse Reactions observed during Placebo-Controlled Trials Reported in ≥5% of OZEMPIC-Treated Patients with Type 2 Diabetes Mellitus
Side effectPlaceboOzempic 0.5 mgOzempic 1 mgMore than placebo, 1 mg
Nausea6.1%15.8%20.3%+14.2 points
Vomiting2.3%5%9.2%+6.9 points
Diarrhea1.9%8.5%8.8%+6.9 points
Abdominal pain4.6%7.3%5.7%+1.1 points
Constipation1.5%5%3.1%+1.6 points

Source: Ozempic label (DailyMed).

Source: FDA (DailyMed) label information.