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GLP-1 Decoder

Wegovy for Teens: Evidence, Eligibility, Coverage

Yes, from age 12: Wegovy is FDA approved for weight loss in children 12 and older. In STEP TEENS, BMI fell 16.1% on average for people on Wegovy, vs 0.6% on placebo.

For teens
From age 12, for weight loss
Active ingredient
semaglutide
How it is taken
weekly injection or daily tablet
Best result (STEP TEENS)
16.1% drop in BMI

Wegovy overview

How long it remains in the body
100%50%25%0%07 d14 d21 d28 d35 d50%25%12.5%time after the dose

Its half-life is about 1 week: after 7 d, half is gone, and about 3% remains after five half-lives (35 d).

How much weight was lost in the main trial
Wegovy (STEP 1)14.9%Placebo2.4%

In STEP 1, people lost 14.9% of body weight over 68 weeks, compared with 2.4% on placebo.

Cost over time
202520262027$1,349.02$0List priceSelf-pay

Prices each month, in US dollars: the list price and the self-pay offers, all taken from the price page of the maker.

Sources: FDA label (DailyMed), healthsystemtracker.org, prnewswire.com 1 2.

Who qualifies?

Which people qualify for Wegovy
SourceWho qualifies
FDA labelFor adults with heart disease plus obesity or overweight, it reduces the risk of heart attack, stroke, and heart-related death (injection and tablets).
FDA labelThis covers long term weight loss and keeping it off, through diet and activity, for adults and children 12 and older who have obesity, and for adults who have overweight and a weight-related condition.
FDA labelIn adults, MASH liver disease with scarring that is moderate to advanced and no cirrhosis is treated with it (injection).
FDA labelIn adults, the tablets are approved for weight loss and for heart risk.

Sources: FDA label (DailyMed).

Teen trial results

Trials of Wegovy in teens
TrialMedicineWho took partLengthPeopleMain resultComparison
STEP TEENS WegovyTeens aged 12 to 17 with obesity68 weeks20116.1% drop in BMI0.6% on placebo

Trial sources: STEP TEENS (PubMed).

What is different for teens?

Wegovy label information for teens
What changesWhat the label says
Acute PancreatitisCan cause inflammation of the pancreas. When severe stomach pain will not stop and sometimes reaches your back, stop the medicine and get care.
Acute Gallbladder DiseaseGallstones and gallbladder inflammation can happen. A fever, pain in the upper right part of the belly, or yellowing of the skin or eyes should be reported.

Per the FDA labels: label on DailyMed.

Warnings listed in the FDA label (DailyMed).

Coverage for teens

Alternatives for teens

GLP-1 medicines and teens
MedicineFor teensHow it is takenTrial result
WegovyFrom age 12, for weight lossweekly injection or daily tablet16.1% drop in BMI
MounjaroFrom age 10, for type 2 diabetesweekly injectionNot listed
TrulicityFrom age 10, for type 2 diabetesweekly injectionNot listed
SaxendaFrom age 12, for weight lossdaily injectionNot listed
VictozaFrom age 10, for type 2 diabetesdaily injectionNot listed
OzempicAdults onlyweekly injectionNot listed
RybelsusAdults onlydaily tabletNot listed
ZepboundAdults onlyweekly injectionNot listed
FoundayoAdults onlydaily tabletNot listed
ByettaAdults onlytwice-daily injectionNot listed

Sources: FDA label (DailyMed), PubMed.

Questions to ask your prescriber

Go through the complete Wegovy prescribing information on DailyMed.