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GLP-1 Decoder

Zepbound for Teens: Evidence, Eligibility, Coverage

No. Zepbound is not approved for anyone under 18. It is approved for adults only: weight loss and sleep apnea.

For teens
Adults only
Active ingredient
tirzepatide
How it is taken
weekly injection

Zepbound in brief

Time this medicine stays in the body
100%50%25%0%05.5 d11 d16.5 d22 d27.5 d50%25%12.5%time after the dose

The half-life is 5 to 6 days. After 5.5 d, half is gone, and after five half-lives (27.5 d), about 3% remains.

Main trial weight loss results
SURMOUNT-1: 5 mg weekly15%SURMOUNT-1: 10 mg weekly19.5%SURMOUNT-1: 15 mg weekly20.9%Placebo3.1%

In SURMOUNT-1, the 72-week result was 20.9% of body weight, compared with 3.1% for placebo.

Cost over time
202420252026$1,086.37$0List priceSelf-pay

Monthly prices in US dollars cover the list price and self-pay offers. Both figures are read from the maker's price page.

Sources: FDA label (DailyMed), Eli Lilly 1 2, cnbc.com.

Who qualifies?

Zepbound: who qualifies
SourceWho qualifies
FDA labelWith diet and activity, it supports weight loss and long-term weight maintenance for adults with obesity, and for adults who are overweight with a weight-related condition.
FDA labelIt treats moderate to severe obstructive sleep apnea in adults with obesity.

Sources: DailyMed FDA label.

What is different for teens?

Teen label points for Zepbound
What changesWhat the label says
Acute Gallbladder DiseaseGallstones and gallbladder inflammation can happen. Pain in the upper right belly, fever, or yellow skin or eyes should be reported.
Acute PancreatitisCan cause inflammation of the pancreas. If severe stomach pain continues, stop taking this medicine and get care.

From the FDA labels: FDA label on DailyMed.

Warnings come from the DailyMed FDA label.

Coverage for teens

Alternatives for teens

GLP-1 medicines and teens
MedicineFor teensHow it is takenTrial result
WegovyFrom age 12, for weight lossweekly injection or daily tablet16.1% drop in BMI
MounjaroFrom age 10, for type 2 diabetesweekly injectionNot listed
TrulicityFrom age 10, for type 2 diabetesweekly injectionNot listed
SaxendaFrom age 12, for weight lossdaily injectionNot listed
VictozaFrom age 10, for type 2 diabetesdaily injectionNot listed
ZepboundAdults onlyweekly injectionNot listed
OzempicAdults onlyweekly injectionNot listed
RybelsusAdults onlydaily tabletNot listed
FoundayoAdults onlydaily tabletNot listed
ByettaAdults onlytwice-daily injectionNot listed

Sources: FDA label (DailyMed), PubMed.

Questions to ask your prescriber

For complete prescribing information, see Zepbound details on DailyMed.