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GLP-1 Decoder

Tirzepatide for Teens: Evidence, Eligibility, Coverage

Yes, for some brands: Mounjaro from age 10 for type 2 diabetes. Zepbound is for adults only.

Brands
Mounjaro and Zepbound

A look at Zepbound

Time it stays in your body
100%50%25%0%05.5 d11 d16.5 d22 d27.5 d50%25%12.5%time after the dose

A half-life lasts 5 to 6 days. Once 5.5 d pass, half is gone; after five half-lives (27.5 d), about 3% is left.

How much weight came off in its main study
SURMOUNT-1: 5 mg weekly15%SURMOUNT-1: 10 mg weekly19.5%SURMOUNT-1: 15 mg weekly20.9%Placebo3.1%

In SURMOUNT-1, over 72 weeks, people lost 20.9% of body weight, compared with 3.1% on placebo.

Costs over time
202420252026$1,086.37$0List priceSelf-pay

The maker's price page lists monthly prices in US dollars for both the list price and self-pay offers.

Sources: FDA label (DailyMed), Eli Lilly 1 2, cnbc.com.

Who qualifies?

Who qualifies for treatment with tirzepatide?
MedicineWho qualifies
MounjaroThis medicine lowers blood sugar for adults and children 10 and older with type 2 diabetes, when used alongside diet and exercise.
MounjaroFor adults with type 2 diabetes at high risk, taking this medicine lowers the risk of heart attack, stroke, or heart-related death.
ZepboundWith diet and activity, it supports weight loss and long-term maintenance for adults who have obesity, or who are overweight with a weight-related condition.
ZepboundIt treats moderate to severe obstructive sleep apnea in adults with obesity.

FDA DailyMed label: 1 and 2.

What is different for teens?

Notes on the tirzepatide label for teens
What changesWhat the label saysLabels
Acute PancreatitisCan cause inflammation of the pancreas. Get medical care and stop the medicine if severe stomach pain persists and sometimes spreads to your back.All of them
Acute Gallbladder DiseaseGallstones and gallbladder inflammation can happen. Report any belly pain in your upper-right area, fever, or yellow skin or eyes.All of them

From FDA labels: FDA DailyMed label.

Label warnings from FDA (DailyMed).

Coverage for teens

Alternatives for teens

GLP-1 medicines and teens
MedicineFor teensHow it is takenTrial result
MounjaroFrom age 10, for type 2 diabetesweekly injectionNot listed
WegovyFrom age 12, for weight lossweekly injection or daily tablet16.1% drop in BMI
TrulicityFrom age 10, for type 2 diabetesweekly injectionNot listed
SaxendaFrom age 12, for weight lossdaily injectionNot listed
VictozaFrom age 10, for type 2 diabetesdaily injectionNot listed
ZepboundAdults onlyweekly injectionNot listed
OzempicAdults onlyweekly injectionNot listed
RybelsusAdults onlydaily tabletNot listed
FoundayoAdults onlydaily tabletNot listed
ByettaAdults onlytwice-daily injectionNot listed

These sources are listed: FDA label on DailyMed, PubMed.

Questions to ask your prescriber