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GLP-1 Decoder

Does Medicare Cover Tirzepatide? Criteria, Copay, How to Appeal

Medicare Part D covers GLP-1s for type 2 diabetes but not for weight loss alone. The Medicare GLP-1 Bridge covers Zepbound for weight loss at $50 a month from July 1, 2026 to December 31, 2027, if you meet its BMI rules.

Medicare GLP-1 Bridge copay
$50 a month
Bridge runs
July 1, 2026 to December 31, 2027
tirzepatide in the Bridge
Some
Part D for weight loss alone
Not covered

Zepbound key facts

Time in the body
100%50%25%0%05.5 d11 d16.5 d22 d27.5 d50%25%12.5%time after the dose

The half-life is 5 to 6 days. At 5.5 d, half is gone, while about 3% remains by the time five half-lives (27.5 d) are done.

Main trial: weight lost
SURMOUNT-1: 5 mg weekly15%SURMOUNT-1: 10 mg weekly19.5%SURMOUNT-1: 15 mg weekly20.9%Placebo3.1%

In SURMOUNT-1 over 72 weeks, 20.9% of body weight was lost, against 3.1% on placebo.

Cost over time
202420252026$1,086.37$0List priceSelf-pay

Monthly prices in US dollars: the list price and self-pay offers, each taken from the manufacturer's price page.

Sources: FDA label (DailyMed), Eli Lilly 1 2, cnbc.com.

Does Medicare cover tirzepatide?

tirzepatide and Medicare
MedicineApproved forPart D coversIn the $50 Bridge
MounjaroType 2 diabetes and heart riskDiabetes and heart-risk usesNo
ZepboundWeight loss and sleep apneaHeart risk or sleep apnea uses onlyYes

Sources: pricinginfo.lilly.com, mounjaro.lilly.com, GoodRx, zepbound.lilly.com.

The published policy

medicare.gov posts the policy itself, so read it there.

Sources: medicare.gov, humana.com, CMS.

Prior authorization checklist

Source: medicare.gov.

Appealing a denial

Denial reasons and fixes
Denial reasonWhat to send or ask
Criteria not metHave your prescriber resubmit the request with your measured BMI and each weight-related condition listed in your chart. The rule requires a BMI of 35, or 27 when you have a weight-related condition.
The drug is not on the plan's listAsk for a formulary exception, and also ask which GLP-1 your plan prefers as an alternative.
  1. Ask your Part D plan for a coverage determination, or for an exception when the drug is not on its list.
  2. If the answer is no, request a redetermination from the plan. Your prescriber can also send a statement to support it.
  3. Should that fail, an outside, independent reviewer receives the appeal.

State and plan differences

Medicare Advantage plans that include drug coverage follow the same rules. Humana is one such plan: for every 30-day supply it lists a Bridge copay of $50.

Because every Part D plan has a separate drug list and copay tiers, diabetes-use copays differ from plan to plan.

If you have Medicare and Medicaid, your state's Medicaid rules apply as well: Does Medicaid Cover Tirzepatide? Criteria, Copay, How to Appeal.

Source: humana.com.

Other choices when coverage says no

If coverage says no
MedicineLowest self-payManufacturer offer if your plan does not cover it
MounjaroNot listed$499 a month
Zepbound$299 a month$299 a month

Sources: pricinginfo.lilly.com, mounjaro.lilly.com, GoodRx, zepbound.lilly.com.