Tirzepatide and Breastfeeding: Milk Transfer Data and Guidance

The Tirzepatide label on breastfeeding: In a small study, breast milk showed undetectable or low levels.

Zepbound in brief

How long it stays in your body

Half-life is 5 to 6 days: after 5.5 d half is gone, and after five half-lives (27.5 d) about 3% is left.

Weight lost in the main trial

In SURMOUNT-1 over 72 weeks, 20.9% of body weight was lost, against 3.1% on placebo.

Cost over time

Monthly prices in US dollars cover the list price and self-pay offers, each taken from the maker's price page.

Tirzepatide label: breastfeeding
Medicine	What the label says
Mounjaro	In a small study, breast milk showed undetectable or low levels.
Zepbound	In a small study, breast milk showed undetectable or low levels.

From the FDA labels: DailyMed label 1 and label 2.

Label warnings, per the FDA DailyMed label.

GLP-1 medicines and breastfeeding
Medicine	What the label says	How it is taken
Mounjaro	In a small study, breast milk showed undetectable or low levels.	weekly injection
Zepbound	In a small study, breast milk showed undetectable or low levels.	weekly injection
Ozempic	Whether it passes into human breast milk is not known.	weekly injection
Wegovy	The tablets contain SNAC, which also appears in breast milk. It is not known whether the injection passes into breast milk.	weekly injection or daily tablet
Rybelsus	The tablets contain SNAC, which breast milk also contains.	daily tablet
Foundayo	Whether it passes into human breast milk is not known.	daily tablet
Trulicity	Whether it passes into human breast milk is not known.	weekly injection
Saxenda	Whether it passes into human breast milk is not known.	daily injection
Victoza	Whether it passes into human breast milk is not known.	daily injection
Byetta	Whether it passes into human breast milk is not known.	twice-daily injection

Source: the FDA DailyMed label.