Tirzepatide and Antidepressants: Is It Safe? Label, Studies
No antidepressant interaction is listed; ask your pharmacist about your specific medicine.
- Verdict
- Ask your prescriber first
- Label names it
- 0 of 2
- General caution
- Pills absorbed more slowly
Check a GLP-1 interaction
A quick look at Zepbound
Its half-life is 5 to 6 days. After 5.5 d, half is gone, and about 3% remains after five half-lives (27.5 d).
In SURMOUNT-1 over 72 weeks, body weight fell 20.9%, compared with 3.1% for placebo.
In US dollars, monthly prices include list prices and self-pay offers, with each figure taken from the manufacturer's price page.
Sources: FDA label (DailyMed), Eli Lilly 1 2, cnbc.com.
Tirzepatide and antidepressants: the verdict
Ask your prescriber first
Word for word from the Mounjaro label, drug interactions section:
“MOUNJARO delays gastric emptying and thereby has the potential to impact the absorption of concomitantly administered oral medications. Caution should be exercised when oral medications”
This comes from the DailyMed FDA label.
What the tirzepatide label says
The Mounjaro label does not name antidepressants. Those statements also apply to Mounjaro.
| Named in the label | The risk | What the label tells doctors |
|---|---|---|
| Oral medicines | Pills absorbed differently | It slows stomach emptying, and this can affect the absorption of other pills. |
According to the Mounjaro label (DailyMed).
What the studies show
- Drug Interactions section label section
- label interaction for oral medicines
This comes from the DailyMed FDA label.
The practical rule
- Keep taking your antidepressant, and report mood changes or worsening side effects to your prescriber.
- Tell your GLP-1 prescriber about every pill you take, including this one.
- If any pills you take must maintain a steady blood level, check with your pharmacist. Your pills may need checks when you start treatment or increase the dose.
This comes from the DailyMed FDA label.
Antidepressants with other GLP-1s
None of the 10 GLP-1 labels names Antidepressants in the drug interaction section. The same general caution for swallowed pills appears on every label, so the answer stays the same across the class.
That question also applies when discussing Ozempic, Wegovy, Mounjaro, Zepbound.
This comes from the DailyMed FDA label.