Zepbound Cost Without Insurance: Vial Prices by Dose
Self-pay starts at $299 a month (LillyDirect: LillyDirect vial or KwikPen 2.5 mg). Zepbound has a list price of $499 to $1,086 per fill before insurance.
- Self-pay from
- $299 a month
- List price
- $499 to $1,086 per fill
- Medicare
- $50 a month
The Zepbound cost without insurance is not one set price. It depends on where you buy it. You can buy it without insurance from manufacturer self-pay programs, TrumpRx, or pharmacy coupons, and each one charges a different price.
Zepbound in brief
The half-life is 5 to 6 days. Half the dose is gone after 5.5 d, and five half-lives (27.5 d) later, about 3% is left.
In SURMOUNT-1 over 72 weeks, the figure was 20.9% of body weight, compared with 3.1% on placebo.
Sources: FDA label (DailyMed).
Zepbound cost without insurance: the price table
| Route | Who it is for | What you pay |
|---|---|---|
| List price | Before insurance or any discount | $499 to $1,086 per fill |
| LillyDirect: LillyDirect vial or KwikPen 2.5 mg | Self-pay, no insurance needed | $299 a month |
| LillyDirect: LillyDirect vial or KwikPen 5 mg | Self-pay, no insurance needed | $399 a month |
| LillyDirect: 7.5 mg through 15 mg (refill within 45 days) | Self-pay, no insurance needed | $449 a month |
| TrumpRx listing (vial, starting) | Self-pay only, not with insurance | $299 a month |
| Walmart Pharmacy: LillyDirect self-pay (lowest dose) | KwikPen | $299 a month |
| Walgreens: self-pay with manufacturer savings card | Cash price at the pharmacy | $299 a month |
| Amazon Pharmacy: cash-pay | KwikPen, 5 mg | $399 a month |
| Amazon Pharmacy: Zepbound Self Pay Journey Program | KwikPen, 7.5 mg to 15 mg | $449 a month |
| GoodRx: GoodRx self-pay | KwikPen | $299 a month |
| H-E-B Pharmacy: self-pay with manufacturer savings | KwikPen | $299 a month |
Prices checked November 2026. Each price links to its source page.
Sources: pricinginfo.lilly.com, zepbound.lilly.com, Eli Lilly, TrumpRx.
By the month and by the year
One year works out to 12 monthly fills. The totals here assume the price does not change all year.
| Route | Who it is for | Per month | Per year (12 fills) |
|---|---|---|---|
| LillyDirect: LillyDirect vial or KwikPen 2.5 mg | Self-pay, no insurance needed | $299 a month | $3,588 |
| LillyDirect: LillyDirect vial or KwikPen 5 mg | Self-pay, no insurance needed | $399 a month | $4,788 |
| LillyDirect: 7.5 mg through 15 mg (refill within 45 days) | Self-pay, no insurance needed | $449 a month | $5,388 |
| TrumpRx listing (vial, starting) | Self-pay only, not with insurance | $299 a month | $3,588 |
| Medicare GLP-1 Bridge | Medicare Part D, for weight management | $50 a month | $600 |
| Walmart Pharmacy: LillyDirect self-pay (lowest dose) | KwikPen | $299 a month | $3,588 |
| Walgreens: self-pay with manufacturer savings card | Cash price at the pharmacy | $299 a month | $3,588 |
| Amazon Pharmacy: cash-pay | KwikPen, 5 mg | $399 a month | $4,788 |
| Amazon Pharmacy: Zepbound Self Pay Journey Program | KwikPen, 7.5 mg to 15 mg | $449 a month | $5,388 |
| GoodRx: GoodRx self-pay | KwikPen | $299 a month | $3,588 |
| H-E-B Pharmacy: self-pay with manufacturer savings | KwikPen | $299 a month | $3,588 |
What changes Zepbound pricing
- Strength: the self-pay amount starts at $299 a month and goes up to $449 a month, based on the strength your prescriber chooses.
- Coupon pricing: GoodRx says its prices shift often and vary from one pharmacy to another.
Source: investors.goodrx.com.
The lowest-cost Zepbound route for your coverage
| If you have | Cheapest route | You pay |
|---|---|---|
| Commercial insurance that covers it | Zepbound Savings Program | As little as $25 for a fill of up to 3 months |
| Commercial insurance that does not cover it | Zepbound savings offer for plans that do not cover it | $299 a month |
| No insurance | LillyDirect: LillyDirect vial or KwikPen 2.5 mg | $299 a month |
| Medicare | Medicare GLP-1 Bridge | $50 a month |
| Medicaid | Your state's Medicaid drug list decides | Zepbound and Medicaid by state |
How Zepbound prices change over time
| Month | Price | What it was |
|---|---|---|
| November 2026 | $499 to $1086.37 per fill | List price (list price range) |
| February 2026 | $299 a month | Self-pay price (KwikPen or vial, 2.5 mg) |
| December 2025 | $299 a month | Self-pay price (2.5 mg vial) |
| December 2025 | $449 a month | Self-pay price (7.5 mg to 15 mg vials, Journey Program) |
| June 2025 | $499 a month | Self-pay price (all vial doses, max) |
| February 2025 | $349 a month | Self-pay price (2.5 mg vial) |
| February 2025 | $499 a month | Self-pay price (7.5 mg and 10 mg vials, Journey Program) |
| August 2024 | $399 a month | Self-pay price (2.5 mg vial) |
| November 2023 | $1,059.87 per fill | List price (list price at launch) |
Sources: pricinginfo.lilly.com, prnewswire.com, Eli Lilly, cnbc.com.
Telehealth services that prescribe Zepbound
The Mochi Health option
$90 a month
Tirzepatide, compounded
Found
$99 a month
Compounded GLP-1 plan
Ro
$299 a month
Zepbound KwikPen at the starting dose
Noom Med
costs $299 a month after the first 4 weeks, with quarterly billing
GLP-1Rx Plus Program (compounded versions of GLP-1 and GIP)
WeightWatchers Med+
$299 a month
Zepbound at the self-pay price
Every price comes from that program's own pricing page. No money comes to us from any of them.
Sources: ro.co, hims.com, noom.com, joinfound.com.