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GLP-1 Decoder

Victoza for Seniors: Evidence, Eligibility, Coverage

Victoza has no separate rule for adults 65 and older. It is approved for type 2 diabetes and heart risk.

Active ingredient
liraglutide
How it is taken
daily injection
Approved for
Type 2 diabetes and heart risk

Victoza overview

How long it remains in your body
100%50%25%0%013 h26 h39 h2.2 d2.7 d50%25%12.5%time after the dose

Its half-life is about 13 hours. After 13 h, half is gone; about 3% remains once five half-lives have passed (2.7 d).

Weight loss from the main trial
Victoza (LEAD-3)2.5 kgPlacebo1.1 kg

In LEAD-3 over 52 weeks with type 2 diabetes, weight loss was 2.5 kg, compared with 1.1 kg on placebo.

Sources: FDA label on DailyMed.

Who qualifies?

Who qualifies to use Victoza
SourceWho qualifies
FDA labelUsed with diet and exercise, this medicine lowers blood sugar in adults and children 10 and older who have type 2 diabetes.
FDA labelFor adults with type 2 diabetes who also have heart disease, the risk of a heart attack, stroke, or heart-related death drops.

Sources: FDA label on DailyMed.

What is different for seniors?

What the Victoza label says about older adults
What changesWhat the label says
HypoglycemiaUsing it together with insulin or a sulfonylurea makes low blood sugar more likely, and those doses may need to be lowered.
Acute Kidney Injury Due to Volume DepletionFluid loss from vomiting or diarrhea may lead to kidney injury. Drink fluids and report heavy fluid loss.
Taken with insulin or sulfonylureasThe chance of low blood sugar goes up if you take this medicine with insulin or a sulfonylurea, for example glipizide or glimepiride. The doctor may reduce those doses.

The source is the FDA labels, shown in the FDA label on DailyMed.

Label warnings: FDA label on DailyMed.

Coverage for seniors

Medicare Part D can cover these medicines when they are prescribed for diabetes or cardiovascular disease.

A GLP-1 may be covered through Part D for fatty liver disease, sleep apnea that is moderate to severe, or type 2 diabetes.

Medicare Part D does not cover a GLP-1 when it is used only for weight loss.

Where Medicaid covers weight-loss GLP-1s, prior authorization is usually required.

Sources: humana.com, medicare.gov, KFF.

Alternatives for seniors

GLP-1 medicines and older adults
MedicineFor older adultsHow it is takenTrial result
VictozaApproved uses applydaily injectionNot listed
OzempicApproved uses applyweekly injectionNot listed
WegovyApproved uses applyweekly injection or daily tablet6.5% for heart attack, stroke, or death from heart disease
RybelsusApproved uses applydaily tabletheart attack, stroke, or death from heart disease: 12%
MounjaroApproved uses applyweekly injectionNot listed
ZepboundApproved uses applyweekly injectionNot listed
FoundayoApproved uses applydaily tabletNot listed
TrulicityApproved uses applyweekly injectionheart attack, stroke, or death from heart disease: 12%
SaxendaApproved uses applydaily injectionNot listed
ByettaApproved uses applytwice-daily injectionNot listed

Label sources: FDA label on DailyMed.

Questions to ask your prescriber

On DailyMed, read all of the Victoza prescribing information.