Ozempic and Antidepressants: Is It Safe? Label, Studies
No antidepressant interaction is listed; ask your pharmacist about your specific medicine.
- Verdict
- Ask your prescriber first
- Label names it
- No
- General caution
- Pills absorbed more slowly
Check a GLP-1 interaction
Ozempic: a quick overview
The half-life is about 1 week; by 7 d, half is gone, and following five half-lives, about 3% remains (35 d).
In SUSTAIN 1, people with type 2 diabetes lost 4.7 kg over 30 weeks, while the placebo group lost 1.2 kg.
In US dollars, monthly prices include list prices and self-pay offers, with each figure read from the maker's price page.
Sources: FDA label (DailyMed), healthsystemtracker.org, prnewswire.com 1 2.
Ozempic and antidepressants: the verdict
Ask your prescriber first
The Ozempic label uses these exact words in its drug interactions section:
“OZEMPIC causes a delay of gastric emptying, and thereby has the potential to impact the absorption of concomitantly administered oral medications. In clinical pharmacology trials,”
Source: FDA label (DailyMed).
Details in the Ozempic label
Antidepressants are not listed in the Ozempic label. These statements in the label still apply to it.
| Named in the label | The risk | What the label tells doctors |
|---|---|---|
| Oral medicines | Pills absorbed differently | This slows stomach emptying and can affect how other pills are absorbed. |
Source: Ozempic label (DailyMed).
What the studies show
- Drug Interactions section label section
- oral medicines label interaction
Source: FDA label (DailyMed).
The practical rule
- Keep taking your antidepressant, and tell your prescriber if your mood changes or side effects get worse.
- Tell the person who prescribes your GLP-1 about every pill you take, including this one.
- Ask your pharmacist if any pills you take require a steady blood level. When you start or increase the dose, these checks may be needed.
Source: FDA label (DailyMed).
Antidepressants with other GLP-1s
None of the 10 GLP-1 labels list Antidepressants in their drug interaction section. Swallowed pills all carry that same general caution, so the answer does not change across the class.
You can ask it about Wegovy, Mounjaro, Zepbound too.
Source: FDA label (DailyMed).