Zepbound and Antidepressants: Is It Safe? Label, Studies
No antidepressant interaction is listed; ask your pharmacist about your specific medicine.
- Verdict
- Ask your prescriber first
- Label names it
- No
- General caution
- Pills absorbed more slowly
Check a GLP-1 interaction
Zepbound in brief
The half-life is 5 to 6 days. By 5.5 d, half has cleared, and about 3% remains once five half-lives are complete (27.5 d).
In SURMOUNT-1 over 72 weeks, body weight fell 20.9% versus 3.1% with placebo.
Monthly prices in US dollars include the list price and self-pay offers, all taken from the maker's price page.
Sources: FDA label (DailyMed), Eli Lilly 1 2, cnbc.com.
Zepbound and antidepressants: the verdict
Ask your prescriber first
Zepbound label: drug interactions section, quoted exactly:
“ZEPBOUND delays gastric emptying and thereby has the potential to impact the absorption of concomitantly administered oral medications. Caution should be exercised when oral medications”
Source: FDA label (DailyMed).
Details from the Zepbound label
No antidepressants are named in the Zepbound label. These statements still apply to it.
| Named in the label | The risk | What the label tells doctors |
|---|---|---|
| Oral medicines | Pills absorbed differently | The medicine slows stomach emptying, so it can change how other pills are absorbed. |
Source: Zepbound label (DailyMed).
What the studies show
- The Drug Interactions part of the label:
- for oral medicines, the label gives this interaction:
Source: FDA label (DailyMed).
The practical rule
- Keep taking your antidepressant, and tell your prescriber if your mood changes or side effects get worse.
- Tell the person who prescribes your GLP-1 about every pill you take, including this one.
- Ask your pharmacist whether any of your pills need to stay at a steady blood level. Those may need checking when you start treatment or increase the dose.
Source: FDA label (DailyMed).
Antidepressants with other GLP-1s
None of the 10 GLP-1 labels names antidepressants in its drug interaction section. The same general caution for pills you swallow is included on every label, so the answer stays the same across the class.
That same question applies to Ozempic, Wegovy, Mounjaro.
Source: FDA label (DailyMed).