Mounjaro and Pregnancy: When to Stop, Risks
The Mounjaro label: Talk to your doctor before you try to conceive; pregnancy data are too limited to judge the risk.
- Active ingredient
- tirzepatide
- How it is taken
- weekly injection
Mounjaro in brief
Its half-life is about 5 days: after 5 d, half is gone, and after five half-lives (25 d), about 3% remains.
In SURPASS-1, people with type 2 diabetes lost 7.8 kg over 40 weeks, compared with 1 kg on placebo.
Monthly prices in US dollars, covering the list price and self-pay offers, with each figure taken from the maker's price page.
Sources: FDA label (DailyMed), healthsystemtracker.org, pricinginfo.lilly.com.
Pregnancy: what the label says
| Medicine | What the label says |
|---|---|
| Mounjaro | Talk to your doctor before you try to conceive; pregnancy data are too limited to judge the risk. |
The FDA labels are the source of these points: FDA label at DailyMed.
What is different for pregnancy?
| What changes | What the label says |
|---|---|
| Taken with birth control pills | Birth control pills may work less well for a time; after you start, and after every dose increase, add a barrier method or choose a non-oral method. |
The FDA labels are the source of these points: FDA label at DailyMed.
Source of these warnings: the label. FDA label at DailyMed.
Each GLP-1 label on pregnancy
| Medicine | What the label says | How it is taken |
|---|---|---|
| Mounjaro | Talk to your doctor before you try to conceive; pregnancy data are too limited to judge the risk. | weekly injection |
 Ozempic | Stop it at least 2 months ahead of a planned pregnancy; pregnancy data are limited. | weekly injection |
 Wegovy | Losing weight while pregnant offers no benefit and may harm the baby; stop once pregnant and at least 2 months before you try to conceive. | weekly injection or daily tablet |
 Rybelsus | Stop it at least 2 months ahead of a planned pregnancy; pregnancy data are limited. | daily tablet |
 Zepbound | No benefit comes from weight loss in pregnancy, and it may harm the baby. | weekly injection |
 Foundayo | No benefit comes from weight loss in pregnancy, and it may harm the baby and use effective birth control while taking it. | daily tablet |
 Trulicity | Talk to your doctor before you try to conceive; pregnancy data are too limited to judge the risk. | weekly injection |
 Saxenda | In pregnancy, weight loss brings no benefit; studies in animals point to a possible risk for the baby. | daily injection |
 Victoza | During pregnancy, use it only if the benefit justifies the possible risk to the baby. | daily injection |
| Byetta | Talk to your doctor before you try to conceive; pregnancy data are too limited to judge the risk. | twice-daily injection |
Listed sources: FDA label on DailyMed
Questions to ask your prescriber
- How far ahead of trying to conceive should I stop?
- What should I do if I become pregnant while taking it?
Read all of the Mounjaro prescribing details at DailyMed.