Semaglutide and Pregnancy: Study Results, Risks

The Semaglutide label: Pregnancy data are limited. If you plan a pregnancy, stop taking it at least 2 months ahead.

A quick look at Wegovy

How long it remains in your body

Its half-life is about 1 week. After 7 d, half is gone, and about 3% remains after five half-lives (35 d).

Weight loss in the main trial

Over 68 weeks, STEP 1 showed 14.9% of body weight lost, against 2.4% on placebo.

Cost over time

The maker's price page shows price points in US dollars each month, covering the list price and self-pay offers.

Pregnancy in the label for semaglutide
Medicine	What the label says
Ozempic	Pregnancy data are limited. If you plan a pregnancy, stop taking it at least 2 months ahead.
Wegovy	Stop the medicine if you are pregnant. Also stop it at least 2 months before you try for a pregnancy. During pregnancy, weight loss offers no benefit and could harm the baby.
Rybelsus	Pregnancy data are limited. If you plan a pregnancy, stop taking it at least 2 months ahead.

DailyMed provides these FDA labels: 1 2 3.

Source for label warnings: FDA label on DailyMed

GLP-1 medicines and pregnancy
Medicine	What the label says	How it is taken
Ozempic	Pregnancy data are limited. If you plan a pregnancy, stop taking it at least 2 months ahead.	weekly injection
Wegovy	Stop the medicine if you are pregnant. Also stop it at least 2 months before you try for a pregnancy. During pregnancy, weight loss offers no benefit and could harm the baby.	weekly injection or daily tablet
Rybelsus	Pregnancy data are limited. If you plan a pregnancy, stop taking it at least 2 months ahead.	daily tablet
Mounjaro	The available pregnancy data are too limited to judge the risk. Discuss it with your doctor before trying to conceive.	weekly injection
Zepbound	During pregnancy, weight loss offers no benefit and could harm the baby. Stop the medicine once a pregnancy is recognized.	weekly injection
Foundayo	During pregnancy, weight loss offers no benefit and could harm the baby. Stop the medicine once a pregnancy is recognized and use effective birth control while taking it.	daily tablet
Trulicity	The available pregnancy data are too limited to judge the risk. Discuss it with your doctor before trying to conceive.	weekly injection
Saxenda	Weight loss has no benefit during pregnancy; animal studies suggest a possible risk to the baby.	daily injection
Victoza	Only use it in pregnancy if the benefit justifies the possible risk to the baby.	daily injection
Byetta	The available pregnancy data are too limited to judge the risk. Discuss it with your doctor before trying to conceive.	twice-daily injection