GLP-1s and Pregnancy: ACOG Guidance, Washout Times
5 of 10 GLP-1 labels say to stop before a planned pregnancy or once pregnancy is found (Ozempic, Wegovy, Rybelsus, Zepbound and Foundayo); the others ask you to weigh the possible risk with your doctor.
A quick look at half-life and weight loss
Half-life in days shows how long the body needs to clear half a dose, according to each FDA label, section 12.3.
Percentage of body weight. Trials, doses, and lengths differ, so check each one against the placebo listed on its own page.
Each GLP-1 label on pregnancy
| Medicine | What the label says | How it is taken |
|---|---|---|
 Ozempic | If you plan a pregnancy, stop at least 2 months before. Pregnancy data are limited. | weekly injection |
 Wegovy | No benefit comes from weight loss in pregnancy, and it may harm the baby. Stop if pregnancy occurs, and stop at least 2 months before you try to conceive. | weekly injection or daily tablet |
 Rybelsus | If you plan a pregnancy, stop at least 2 months before. Pregnancy data are limited. | daily tablet |
 Mounjaro | There is not enough pregnancy data to judge the risk; talk with your doctor before trying to conceive. | weekly injection |
 Zepbound | Weight loss during pregnancy offers no benefit and may harm the baby. | weekly injection |
 Foundayo | Weight loss during pregnancy offers no benefit and may harm the baby and use effective birth control while taking it. | daily tablet |
 Trulicity | There is not enough pregnancy data to judge the risk; talk with your doctor before trying to conceive. | weekly injection |
 Saxenda | Animal studies point to a possible risk for the baby, while weight loss in pregnancy brings no benefit. | daily injection |
 Victoza | During pregnancy, use it only if the benefit is enough to justify any possible risk to the baby. | daily injection |
| Byetta | There is not enough pregnancy data to judge the risk; talk with your doctor before trying to conceive. | twice-daily injection |
Sources: FDA label (DailyMed).
During pregnancy, what is different?
| What changes | What the label says | Labels |
|---|---|---|
| Taken with birth control pills | Birth control pills may work less well for a while because of it. After you start and after each dose increase, use a method that is not oral, or add a barrier method. | Mounjaro, Zepbound and Foundayo |
Information from FDA labels: FDA label at DailyMed.
These warnings come from the FDA label at DailyMed.
Questions to ask your prescriber
- When should I stop taking it before trying to conceive?
- What should I do if I become pregnant while taking it?