Ozempic and Adderall: Absorption
No interaction is listed, but both can curb appetite; ask your prescriber before combining.
- Verdict
- Ask your prescriber first
- Label names it
- No
- General caution
- Pills absorbed more slowly
Check a GLP-1 interaction
Ozempic facts at a glance
Its half-life is about 1 week: after 7 d, half is gone, and after five half-lives (35 d), about 3% remains.
In the 30-week SUSTAIN 1 trial involving type 2 diabetes, participants lost 4.7 kg compared with 1.2 kg on placebo.
Monthly prices in US dollars include the list price and self-pay offers, all taken from the maker's price page.
Sources: FDA label (DailyMed), healthsystemtracker.org, prnewswire.com 1 2.
Ozempic and Adderall: the verdict
Ask your prescriber first
The Ozempic label says this in its drug interactions section, word for word:
“OZEMPIC causes a delay of gastric emptying, and thereby has the potential to impact the absorption of concomitantly administered oral medications. In clinical pharmacology trials,”
Source: the FDA DailyMed label.
Guidance from the Ozempic label
The Ozempic label does not mention Adderall. The lines that still apply to it are these.
| Named in the label | The risk | What the label tells doctors |
|---|---|---|
| Oral medicines | Pills absorbed differently | Because stomach emptying slows, the absorption of other pills may change. |
This comes from the Ozempic label (DailyMed).
What the studies show
- Drug Interactions section label section
- anorexia and weight loss: the side effect
Source: the FDA DailyMed label.
The practical rule
- Tell your prescriber that you take both, and report if your heart is racing or if you are eating very little.
- Tell the person who prescribes your GLP-1 about every pill you take, including this one.
- Ask your pharmacist if any pills you take require a steady blood level. When you start or raise the dose, those may need checking.
Source: the FDA DailyMed label.
Adderall with other GLP-1s
None of the 10 GLP-1 labels includes Adderall in a drug interaction section. Swallowed pills carry the same general warning in each label, so the answer does not change for the whole class.
The same question applies to Wegovy, Mounjaro, Zepbound.
Source: the FDA DailyMed label.