Zepbound and Adderall: Heart Rate, Appetite
No interaction is listed, but both can curb appetite; ask your prescriber before combining.
- Verdict
- First, ask your prescriber
- Label names it
- No
- General caution
- Pills absorbed more slowly
Check a GLP-1 interaction
A quick look at Zepbound
The half-life is 5 to 6 days. After 5.5 d, half is gone, and about 3% remains after five half-lives (27.5 d).
In SURMOUNT-1, participants lost 20.9% of body weight over 72 weeks, compared with 3.1% on placebo.
Monthly amounts in US dollars are based on the maker's price page, which includes both list prices and self-pay offers.
Sources: FDA label (DailyMed), Eli Lilly 1 2, cnbc.com.
Zepbound and Adderall: the verdict
First, ask your prescriber
The Zepbound label’s drug interactions section gives the following wording word for word:
“ZEPBOUND delays gastric emptying and thereby has the potential to impact the absorption of concomitantly administered oral medications. Caution should be exercised when oral medications”
Source: FDA label (DailyMed).
What the Zepbound label says
The Zepbound label does not name Adderall. These label statements continue to apply to it.
| Named in the label | The risk | What the label tells doctors |
|---|---|---|
| Oral medicines | Pills absorbed differently | The stomach empties more slowly, which can change how other pills are absorbed. |
Source: Zepbound label (DailyMed).
What the studies show
- Drug Interactions section label section
- anorexia and weight loss as a side effect
Source: FDA label (DailyMed).
The practical rule
- Tell your prescriber that you take both. Mention if you eat very little or your heart races.
- Tell whoever prescribes your GLP-1 about every pill you take, including this one.
- Ask your pharmacist whether any pill you take needs a steady blood level. You may need checks on those when you start or after a dose increase.
Source: FDA label (DailyMed).
Adderall with other GLP-1s
None of the 10 GLP-1 labels names Adderall in the drug interaction section. For swallowed pills, every label gives the same general warning, so the answer is the same for the whole group.
The same question applies to Ozempic, Wegovy, Mounjaro.
Source: FDA label (DailyMed).