Zepbound and Coffee: Is It Safe? Label, Studies
No caffeine interaction is listed; normal amounts of coffee are fine for most adults.
- Verdict
- Generally fine together
- Label names it
- No
Check a GLP-1 interaction
A quick look at Zepbound
The half-life lasts 5 to 6 days. At 5.5 d, half is gone, and five half-lives leave about 3% behind (27.5 d).
At 72 weeks, SURMOUNT-1 showed 20.9% of body weight, compared with 3.1% on placebo.
Monthly US dollar prices include the list price and self-pay offers, with each figure taken from the maker's price page.
Sources: FDA label (DailyMed), Eli Lilly 1 2, cnbc.com.
Zepbound and coffee: the verdict
Generally fine together
The Zepbound label lists no interaction with caffeine. For healthy adults, the FDA cites 400 milligrams of caffeine daily as not generally linked to harm. This is roughly equivalent to two to three cups of coffee.
What the Zepbound label states
No line on coffee. The main warning about drinks relates to kidney injury from fluid loss. Fluid loss from vomiting or diarrhea may lead to kidney injury. Drink fluids and report heavy fluid loss.
Source: FDA label (DailyMed).
What the studies show
- The Drug Interactions section of the
- 400 mg caffeine per day
- Acute Kidney Injury Due to Volume Depletion warning in the label
Sources: FDA label (DailyMed), FDA.
The rule to follow in practice
If coffee worsens nausea or heartburn, drink less of it and more water, because vomiting and diarrhea can dehydrate you.
Source: FDA label (DailyMed).
Coffee with other GLP-1s
Coffee is not listed in the drug interaction section of any of the 10 GLP-1 labels, so the answer is the same for the whole class.
The same question also concerns Ozempic, Wegovy, Rybelsus, Mounjaro, Trulicity, Saxenda, Victoza.