Ozempic Mental Side Effects: Mood, Anxiety, Memory
The Ozempic label does not list mood changes as a side effect. What people mean by it: feeling down, anxious or not like yourself.
- In the label
- Not listed
- Most common in the label
- Nausea 20.3%
Ozempic in brief
Its half-life is about 1 week. After 7 d, half is gone; once five half-lives (35 d) pass, about 3% is left.
SUSTAIN 1 ran 30 weeks in people with type 2 diabetes. Weight loss reached 4.7 kg, versus 1.2 kg for placebo.
In US dollars, the monthly prices include both the list price and self-pay offers. Each figure comes from the maker's price page.
Sources: FDA label (DailyMed), healthsystemtracker.org, prnewswire.com 1 2.
What the Ozempic label lists instead
The Ozempic label does not list mood changes. Those are the five side effects that the label lists most often.
| Side effect | Placebo | Ozempic 0.5 mg | Ozempic 1 mg | More than placebo, 1 mg |
|---|---|---|---|---|
| Nausea | 6.1% | 15.8% | 20.3% | +14.2 points |
| Vomiting | 2.3% | 5% | 9.2% | +6.9 points |
| Diarrhea | 1.9% | 8.5% | 8.8% | +6.9 points |
| Abdominal pain | 4.6% | 7.3% | 5.7% | +1.1 points |
| Constipation | 1.5% | 5% | 3.1% | +1.6 points |
The source is the Ozempic label (DailyMed).
Mood on Ozempic compared with other GLP-1s
Every label reports on its own trials, and those trials involve different groups of people. Use this as a rough guide.
| Medicine | Highest rate in the label | Dose group | Placebo | People in the trials |
|---|---|---|---|---|
 Wegovy | 4% | 2.4 mg | 2% | Children 12 and older with obesity |
 Saxenda | 2% | all doses | 1.6% | Adults with obesity or overweight (weight management) |
| Ozempic | Not listed | – | – | – |
 Rybelsus | Not listed | – | – | – |
 Mounjaro | Not listed | – | – | – |
 Zepbound | Not listed | – | – | – |
 Foundayo | Not listed | – | – | – |
 Trulicity | Not listed | – | – | – |
 Victoza | Not listed | – | – | – |
| Byetta | Not listed | – | – | – |
Sources: the Wegovy label (DailyMed) plus the Saxenda label (DailyMed).
Source: the FDA label (DailyMed).