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GLP-1 Decoder

Ozempic Liver: How Common, How Long It Lasts, What Helps

Liver effects are not listed on the Ozempic label as a side effect. What people mean by it: changes in liver blood tests or liver problems.

In the label
Not listed
Most common in the label
Nausea 20.3%

Ozempic in brief

How long it lasts in the body
100%50%25%0%07 d14 d21 d28 d35 d50%25%12.5%time after the dose

Its half-life is about 1 week: after 7 d half is gone, and about 3% remains after five half-lives (35 d).

Weight loss in its main trial
Ozempic (SUSTAIN 1)4.7 kgPlacebo1.2 kg

Weight loss during SUSTAIN 1 was 4.7 kg after 30 weeks in type 2 diabetes, compared with 1.2 kg on placebo.

Prices over time
202520262027$1,027.51$0List priceSelf-pay

Monthly US-dollar figures cover the list price and self-pay offers, based on the maker's price page.

Sources: FDA label (DailyMed), healthsystemtracker.org, prnewswire.com 1 2.

What the Ozempic label lists instead

Liver effects are not listed on the Ozempic label. The five side effects it lists most often are these.

Table 1. Adverse Reactions in Placebo-Controlled Trials Reported in ≥5% of OZEMPIC-Treated Patients with Type 2 Diabetes Mellitus
Side effectPlaceboOzempic 0.5 mgOzempic 1 mgMore than placebo, 1 mg
Nausea6.1%15.8%20.3%+14.2 points
Vomiting2.3%5%9.2%+6.9 points
Diarrhea1.9%8.5%8.8%+6.9 points
Abdominal pain4.6%7.3%5.7%+1.1 points
Constipation1.5%5%3.1%+1.6 points

Source: Ozempic label (DailyMed).

Source: FDA label (DailyMed).