Ozempic Insomnia: How Common, How Long It Lasts, What Helps
The Ozempic label does not list trouble sleeping as a side effect. What people mean by it: trouble falling or staying asleep.
- In the label
- Not listed
- Most common in the label
- Nausea 20.3%
Ozempic facts at a glance
Its half-life is about 1 week: after 7 d, half is gone, and after five half-lives (35 d), about 3% remains.
Across SUSTAIN 1, which ran 30 weeks, people with type 2 diabetes lost 4.7 kg. Placebo participants lost 1.2 kg.
Monthly amounts are given in US dollars for both the list price and self-pay offers. Each amount came from the maker's price page.
Sources: FDA label (DailyMed), healthsystemtracker.org, prnewswire.com 1 2.
What the Ozempic label lists in its place
The Ozempic label does not list trouble sleeping. The five side effects it lists most often are shown here.
| Side effect | Placebo | Ozempic 0.5 mg | Ozempic 1 mg | More than placebo, 1 mg |
|---|---|---|---|---|
| Nausea | 6.1% | 15.8% | 20.3% | +14.2 points |
| Vomiting | 2.3% | 5% | 9.2% | +6.9 points |
| Diarrhea | 1.9% | 8.5% | 8.8% | +6.9 points |
| Abdominal pain | 4.6% | 7.3% | 5.7% | +1.1 points |
| Constipation | 1.5% | 5% | 3.1% | +1.6 points |
This information comes from Ozempic label (DailyMed).
Ozempic insomnia compared with other GLP-1s
Each label describes its own trials, and those trials involved different groups of people. Treat it as a rough guide.
| Medicine | Highest rate in the label | Dose group | Placebo | People in the trials |
|---|---|---|---|---|
 Saxenda | 2.4% | all doses | 1.7% | Adults with obesity or overweight (weight management) |
| Ozempic | Not listed | – | – | – |
 Wegovy | Not listed | – | – | – |
 Rybelsus | Not listed | – | – | – |
 Mounjaro | Not listed | – | – | – |
 Zepbound | Not listed | – | – | – |
 Foundayo | Not listed | – | – | – |
 Trulicity | Not listed | – | – | – |
 Victoza | Not listed | – | – | – |
| Byetta | Not listed | – | – | – |
Source: Saxenda label (DailyMed).
Information source: FDA label (DailyMed).