Ozempic and Trouble Sleeping: Is Insomnia a Side Effect?
The Ozempic label does not include trouble sleeping as a side effect. What people mean by it: trouble falling or staying asleep.
- In the label
- Not listed
- Most common in the label
- Nausea 20.3%
Ozempic overview
Its half-life is about 1 week. By 7 d, half has gone; after five half-lives (35 d), about 3% remains.
In SUSTAIN 1, which lasted 30 weeks, people with type 2 diabetes lost 4.7 kg, compared with 1.2 kg on placebo.
Monthly prices in US dollars include list prices and self-pay offers. Each price is read from the maker's price page.
Sources: FDA label (DailyMed), healthsystemtracker.org, prnewswire.com 1 2.
What the Ozempic label covers instead
The Ozempic label does not include trouble sleeping. These five side effects are the ones listed most often.
| Side effect | Placebo | Ozempic 0.5 mg | Ozempic 1 mg | More than placebo, 1 mg |
|---|---|---|---|---|
| Nausea | 6.1% | 15.8% | 20.3% | +14.2 points |
| Vomiting | 2.3% | 5% | 9.2% | +6.9 points |
| Diarrhea | 1.9% | 8.5% | 8.8% | +6.9 points |
| Abdominal pain | 4.6% | 7.3% | 5.7% | +1.1 points |
| Constipation | 1.5% | 5% | 3.1% | +1.6 points |
Source: Ozempic label (DailyMed).
Sleep trouble on Ozempic compared with other GLP-1s
Each label covers its own trials, and each set of trials used a different group of people. Consider this a rough guide.
| Medicine | Highest rate in the label | Dose group | Placebo | People in the trials |
|---|---|---|---|---|
 Saxenda | 2.4% | all doses | 1.7% | Adults with obesity or overweight (weight management) |
| Ozempic | Not listed | – | – | – |
 Wegovy | Not listed | – | – | – |
 Rybelsus | Not listed | – | – | – |
 Mounjaro | Not listed | – | – | – |
 Zepbound | Not listed | – | – | – |
 Foundayo | Not listed | – | – | – |
 Trulicity | Not listed | – | – | – |
 Victoza | Not listed | – | – | – |
| Byetta | Not listed | – | – | – |
Source: Saxenda label (DailyMed).
Source: FDA label (DailyMed).