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GLP-1 Decoder

Ozempic and Sex Drive: What Studies Show, Why Libido Shifts

The Ozempic label does not list sex drive changes as a side effect. What people mean by it: more or less interest in sex than usual.

In the label
Not listed
Most common in the label
Nausea 20.3%

A quick look at Ozempic

How long it stays in your body
100%50%25%0%07 d14 d21 d28 d35 d50%25%12.5%time after the dose

Its half-life is about 1 week: after 7 d, half of it is gone, and about 3% remains after five half-lives (35 d).

Main trial: how much weight was lost
Ozempic (SUSTAIN 1)4.7 kgPlacebo1.2 kg

In the SUSTAIN 1 trial of 30 weeks, people with type 2 diabetes lost 4.7 kg, against 1.2 kg on placebo.

Price as time goes on
202520262027$1,027.51$0List priceSelf-pay

Prices are given in US dollars each month: the list price and the self-pay offers, all taken from the maker's price page.

Sources: FDA label (DailyMed), healthsystemtracker.org, prnewswire.com 1 2.

What the Ozempic label lists instead

The Ozempic label does not list sex drive changes. Those five side effects are the ones the label reports most often.

Table 1. In patients with Type 2 Diabetes Mellitus: Adverse Reactions Seen in Placebo-Controlled Trials Reported in ≥5% of OZEMPIC-Treated Patients
Side effectPlaceboOzempic 0.5 mgOzempic 1 mgMore than placebo, 1 mg
Nausea6.1%15.8%20.3%+14.2 points
Vomiting2.3%5%9.2%+6.9 points
Diarrhea1.9%8.5%8.8%+6.9 points
Abdominal pain4.6%7.3%5.7%+1.1 points
Constipation1.5%5%3.1%+1.6 points

Source: Ozempic label (DailyMed).

Taken from the FDA label (DailyMed).