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GLP-1 Decoder

Ozempic Joint Pain: How Common, How Long It Lasts

The Ozempic label does not include joint pain as a side effect. What people mean by it: aching or stiff joints.

In the label
Not listed
Most common in the label
Nausea 20.3%

Ozempic key facts

How long the drug remains in the body
100%50%25%0%07 d14 d21 d28 d35 d50%25%12.5%time after the dose

Its half-life is about 1 week: after 7 d, half is gone, while about 3% remains after five half-lives (35 d).

Weight loss in the main trial
Ozempic (SUSTAIN 1)4.7 kgPlacebo1.2 kg

People with type 2 diabetes in SUSTAIN 1 lost 4.7 kg over 30 weeks, compared with 1.2 kg on placebo.

The price as time goes on
202520262027$1,027.51$0List priceSelf-pay

In US dollars, monthly prices include the list price and self-pay offers. Each amount comes from the maker's price page.

Sources: FDA label (DailyMed), healthsystemtracker.org, prnewswire.com 1 2.

What appears on the Ozempic label instead

The Ozempic label does not include joint pain. These five side effects appear most often on the label.

Table 1. Adverse Reactions from Placebo-Controlled Trials Reported in ≥5% of OZEMPIC-Treated Patients with Type 2 Diabetes Mellitus
Side effectPlaceboOzempic 0.5 mgOzempic 1 mgMore than placebo, 1 mg
Nausea6.1%15.8%20.3%+14.2 points
Vomiting2.3%5%9.2%+6.9 points
Diarrhea1.9%8.5%8.8%+6.9 points
Abdominal pain4.6%7.3%5.7%+1.1 points
Constipation1.5%5%3.1%+1.6 points

See the source: Ozempic label (DailyMed).

Source: FDA label on DailyMed.