Tirzepatide Cost: Zepbound, Mounjaro and Compounded Prices
Without insurance, the lowest tirzepatide self-pay price is $299 a month, for LillyDirect vial or KwikPen 2.5 mg. List prices run far higher.
- Lowest self-pay
- $299 a month
- Medicines compared
- 2
- Highest list price
- $1,112.16 per fill
Your tirzepatide cost changes with the medicine you choose, its strength, and where you get it. Manufacturers offer self-pay programs that usually come at a much lower price than the list price.
A quick look at Zepbound
The half-life is 5 to 6 days, so half is gone after 5.5 d. By five half-lives (27.5 d), about 3% remains.
The SURMOUNT-1 trial ran for 72 weeks. People lost 20.9% of body weight there, versus 3.1% on placebo.
The monthly price points in US dollars cover both the list price and self-pay offers. Each one is taken from the maker's price page.
Sources: FDA label (DailyMed), Eli Lilly 1 2, cnbc.com.
Monthly and yearly prices
Prices checked November 2026. Every price links to the page where it appears.
Sources: pricinginfo.lilly.com, mounjaro.lilly.com, GoodRx, zepbound.lilly.com.
What a full year costs at the lowest self-pay rate
| Medicine | Lowest self-pay route | Per month | Per year (12 fills) |
|---|---|---|---|
 Zepbound | LillyDirect: LillyDirect vial or KwikPen 2.5 mg | $299 a month | $3,588 |
Sources: pricinginfo.lilly.com, mounjaro.lilly.com, GoodRx, zepbound.lilly.com.
Price pages for each medicine
Monthly prices for telehealth programs
The Mochi Health program
$60 a month
Compounded semaglutide
Found
$99 a month
Compounded GLP-1 plan
Ro
$149 a month
The first dose of the Wegovy pill
The Hims & Hers program
$149 a month
Wegovy in pill form
The WeightWatchers Med+ plan
$149 a month
Self-pay Foundayo pill
Every price shown comes from the pricing page of that program. We do not earn any money from any of them.
Sources: ro.co, hims.com, henrymeds.com, noom.com.