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GLP-1 Decoder

Rybelsus Vial: What It Is, Price and How It Differs from the Pen

Rybelsus vial: which forms exist, which are FDA approved, and how they differ.

Active ingredient
semaglutide
Manufacturer
Novo Nordisk
How it is taken
Daily pill
FDA-approved for
Type 2 diabetes, Heart risk
Rybelsus vial: GLP-1 medicines as a pen, a pill and a vial

Rybelsus in brief

How long it remains in your body
100%50%25%0%07 d14 d21 d28 d35 d50%25%12.5%time after the dose

Its half-life runs about 1 week. After 7 d, half is gone, and five half-lives (35 d) leave about 3% behind.

Weight dropped in the main trial
Rybelsus (PIONEER 1)3.7 kgPlacebo1.4 kg

In PIONEER 1, people with type 2 diabetes lost 3.7 kg over 26 weeks, compared with 1.4 kg on placebo.

How the price changes over time
20262027$1,027.51$0List priceSelf-pay

Prices by month in US dollars include the list price and self-pay offers. Each figure comes from the maker's price page.

Sources: FDA label (DailyMed), healthsystemtracker.org, Novo Nordisk pricing, Novo Nordisk.