Ozempic vs Adlyxin: Weight Loss, Side Effects, Price
Ozempic is a GLP-1 medicine (weekly injection); Adlyxin is lixisenatide is a GLP-1 injection for type 2 diabetes, given daily. Ozempic is FDA approved for heart risk and type 2 diabetes, plus kidney disease affecting people who have type 2 diabetes.
Ozempic in brief
Its half-life is about 1 week: after 7 d, half is gone, and about 3% remains after five half-lives (35 d).
In SUSTAIN 1, people with type 2 diabetes lost 4.7 kg over 30 weeks, against 1.2 kg on placebo.
In US dollars, monthly price points include the list price and self-pay offers, with each one read from the maker's price page.
Sources: FDA label (DailyMed), healthsystemtracker.org, prnewswire.com 1 2.
Comparing Ozempic and Adlyxin side by side
| Ozempic | Adlyxin | |
|---|---|---|
| Medicine | Ozempic | Adlyxin |
| Active ingredient | semaglutide | Not listed |
| Manufacturer | Novo Nordisk | Not listed |
| How it is taken | Weekly injection | Not listed |
| Approved for | Heart risk and type 2 diabetes, plus kidney disease affecting people who have type 2 diabetes | Not listed |
| First FDA approval | 2017 | Not listed |
| Most common side effect | Nausea 20.3% vs 6.1% on placebo | Not listed |
| List price | $1,027.51 per pen | Not listed |
| Self-pay from | $199 per month | Not listed |
| FDA shortage | Resolved February 21, 2025 | Not listed |
| What it is | Not listed | Lixisenatide is a GLP-1 injection for type 2 diabetes, given daily |
Sources: FDA label, FDA label (DailyMed), Novo Nordisk pricing, TrumpRx.
Cost and coverage side by side
| Medicine | How you pay | Price |
|---|---|---|
| Ozempic | List price before insurance | $1,027.51 per pen |
| Ozempic | Ozempic Savings Offer (insured) | a monthly price starting at $25 for up to 3 months |
| Ozempic | Self-pay: Ozempic pill (from 1.5 mg) | $149 per month |
| Ozempic | Self-pay intro offer for the Ozempic pen: the first 2 fills use 0.25 mg and 0.5 mg | $199 per month |
| Ozempic | Self-pay: the Ozempic pen in 0.25 mg, 0.5 mg, and 1 mg doses | $349 per month |
| Ozempic | Self-pay: Ozempic pen 2 mg | $499 per month |
| Ozempic | Self-pay via TrumpRx | $199 per month |
In November 2026, the prices were checked using these pages: Novo Nordisk pricing, NovoCare, TrumpRx