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GLP-1 Decoder

Ozempic for Thyroid Conditions: Evidence, Eligibility

Ozempic is not for anyone with a personal or family history of medullary thyroid cancer (MTC) or MEN 2. Other thyroid conditions are not on its list of reasons not to take it.

For thyroid conditions
Not for MTC or MEN 2 history
Active ingredient
semaglutide
How it is taken
weekly injection

Ozempic in brief

Time it remains in the body
100%50%25%0%07 d14 d21 d28 d35 d50%25%12.5%time after the dose

The half-life is about 1 week: by 7 d only half remains, and by five half-lives (35 d) just about 3% is left.

Weight loss in the main trial
Ozempic (SUSTAIN 1)4.7 kgPlacebo1.2 kg

In SUSTAIN 1, people with type 2 diabetes lost 4.7 kg over 30 weeks, compared with 1.2 kg on placebo.

Cost over time
202520262027$1,027.51$0List priceSelf-pay

Monthly prices in US dollars include the list price and self-pay offers, each taken from the maker's price page.

Sources: FDA label (DailyMed), healthsystemtracker.org, prnewswire.com 1 2.

Who qualifies?

Ozempic: who qualifies
SourceWho qualifies
FDA labelWhen used with diet and exercise, it lowers blood sugar in adults with type 2 diabetes.
FDA labelIn adults with type 2 diabetes and heart disease, it lowers the risk of heart attack, stroke and heart-related death.
FDA labelAmong adults with both chronic kidney disease and type 2 diabetes, it lowers the risk of worsening kidney disease, kidney failure and heart-related death.

Sources: FDA label (DailyMed).

What is different when thyroid conditions are involved?

Ozempic label details for thyroid conditions
What changesWhat the label says
Risk of Thyroid C-Cell TumorsIn rodents it caused thyroid C-cell tumors, and whether people get them from it is unknown. If medullary thyroid cancer (MTC) is in your personal or family history, or you have MEN 2, you should not take it.

Source: DailyMed FDA label.

Label warnings source: DailyMed FDA label.

Coverage for thyroid conditions

Other options for thyroid conditions

GLP-1 medicines and thyroid conditions
MedicineFor thyroid conditionsHow it is taken
ByettaNo thyroid warningtwice-daily injection
OzempicNot for MTC or MEN 2 historyweekly injection
WegovyNot for MTC or MEN 2 historyweekly injection or daily tablet
RybelsusNot for MTC or MEN 2 historydaily tablet
MounjaroNot for MTC or MEN 2 historyweekly injection
ZepboundNot for MTC or MEN 2 historyweekly injection
FoundayoNot for MTC or MEN 2 historydaily tablet
TrulicityNot for MTC or MEN 2 historyweekly injection
SaxendaNot for MTC or MEN 2 historydaily injection
VictozaNot for MTC or MEN 2 historydaily injection

Sources: FDA label (DailyMed).

Ask your prescriber these questions

Read the complete prescribing details for Ozempic on DailyMed.