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GLP-1 Decoder

Tirzepatide with B12: Lilly's Impurity Warning, Risks

Tirzepatide and b12: what compounded versions are, their FDA status, and the risks.

Active ingredient
tirzepatide
FDA status
Compounded copies are not FDA approved

A quick look at Zepbound

How long it remains in the body
100%50%25%0%05.5 d11 d16.5 d22 d27.5 d50%25%12.5%time after the dose

Its half-life spans 5 to 6 days. By 5.5 d half is gone, and about 3% is left once five half-lives have passed, which comes to 27.5 d.

How much weight was lost in its main trial
SURMOUNT-1: 5 mg weekly15%SURMOUNT-1: 10 mg weekly19.5%SURMOUNT-1: 15 mg weekly20.9%Placebo3.1%

In SURMOUNT-1 after 72 weeks, the result was 20.9% of body weight, compared with 3.1% on placebo.

How the price changes over time
202420252026$1,086.37$0List priceSelf-pay

In US dollars, monthly price points cover list price and self-pay offers. Every figure was read from the price page published by the maker.

Sources: FDA label (DailyMed), Eli Lilly 1 2, cnbc.com.