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GLP-1 Decoder

How Tirzepatide Works (and How Fast)

Tirzepatide how it works: a plain explanation, with the facts from the prescribing information.

Active ingredient
tirzepatide
Manufacturer
Eli Lilly
Tirzepatide how it works: GLP-1 medicines as a pen, a pill and a vial

Zepbound: the short version

Time the medicine remains in your body
100%50%25%0%05.5 d11 d16.5 d22 d27.5 d50%25%12.5%time after the dose

The half-life is 5 to 6 days. Once 5.5 d pass, half is gone, and about 3% remains after five half-lives (27.5 d).

Main trial results: weight lost
SURMOUNT-1: 5 mg weekly15%SURMOUNT-1: 10 mg weekly19.5%SURMOUNT-1: 15 mg weekly20.9%Placebo3.1%

In SURMOUNT-1 over 72 weeks, body weight fell 20.9%, compared with 3.1% in the placebo group.

How the price changes over time
202420252026$1,086.37$0List priceSelf-pay

The maker's price page provides monthly price points in US dollars, including list price and self-pay offers.

Sources: FDA label (DailyMed), Eli Lilly 1 2, cnbc.com.