How Tirzepatide Works (and How Fast)
Tirzepatide how it works: a plain explanation, with the facts from the prescribing information.
- Active ingredient
- tirzepatide
- Manufacturer
- Eli Lilly

Zepbound: the short version
The half-life is 5 to 6 days. Once 5.5 d pass, half is gone, and about 3% remains after five half-lives (27.5 d).
In SURMOUNT-1 over 72 weeks, body weight fell 20.9%, compared with 3.1% in the placebo group.
The maker's price page provides monthly price points in US dollars, including list price and self-pay offers.
Sources: FDA label (DailyMed), Eli Lilly 1 2, cnbc.com.