Semaglutide vs Rybelsus: Weight Loss, Side Effects, Price

Rybelsus and Semaglutide side by side

Every row lists the same ingredient, while each brand's label defines its approved uses, forms, and price.

Every semaglutide brand, Rybelsus first

Medicine	Ingredient	How it is taken	Approved for	Trial weight loss	Most common side effect	Self-pay from	List price
Rybelsus	semaglutide	Daily tablet	Type 2 diabetes and heart risk	Not listed	Nausea 20% vs 6% on placebo	Not listed	$1,027.51 per 30 tablets
Ozempic	semaglutide	Weekly injection	Type 2 diabetes and heart risk; also kidney disease in type 2 diabetes	Not listed	Nausea 20.3% vs 6.1% on placebo	$199 per month	$1,027.51 per pen
Wegovy	semaglutide	Weekly injection or daily tablet	Weight loss, heart risk and MASH liver disease	14.9%	Nausea 44% vs 16% on placebo	$149 per month	$1,349.02 per month

Comparing prices and coverage

Prices for each route before and after savings

Medicine	How you pay	Price
Rybelsus	List price before insurance	$1,027.51 per 30 tablets
Rybelsus	RYBELSUS Savings Offer (insured)	for 1, 2 or 3 months per fill, the price starts at $25
Ozempic	List price before insurance	$1,027.51 per pen
Ozempic	Ozempic Savings Offer (insured)	starting at $25 a month for a span of up to 3 months
Ozempic	Self-pay: Ozempic pill (from 1.5 mg)	$149 per month
Wegovy	List price before insurance	$1,349.02 per month
Wegovy	Wegovy Savings Offer (insured)	from $25 per month
Wegovy	Self-pay: Wegovy pill 1.5 mg	$149 per month
Wegovy	Medicare GLP-1 Bridge (Wegovy, eligible Part D)	$50 per month

Generic and compounded forms of semaglutide

On February 21, 2025, the injection shortage was resolved. Older Rybelsus tablets are being discontinued.

Sources: FDA 1 2.

• Is There a Generic Rybelsus? Status, Timeline, and What Counts
• Compounded Semaglutide