Natural Ozempic? Berberine, Fiber and BRP: What the Evidence Says
No supplement or diet is FDA approved to do what Ozempic does. The proven alternatives are other prescription GLP-1s such as Wegovy, Rybelsus and Mounjaro, plus eating and activity changes that help with any of them.
- Same-use GLP-1 options
- 6
- Needle-free options
- Wegovy and Rybelsus
- Lowest self-pay alternative
- $149 per month, Wegovy
Ozempic in brief
The half-life is about 1 week. At 7 d, half has left the body, and about 3% is still there after five half-lives (35 d).
In SUSTAIN 1 over 30 weeks among people with type 2 diabetes, weight loss was 4.7 kg versus 1.2 kg for placebo
Prices each month in US dollars cover the list price and self-pay offers, and each one comes from the maker's price page.
Sources: FDA label (DailyMed), healthsystemtracker.org, prnewswire.com 1 2.
Prescription alternatives to Ozempic
| Medicine | Ingredient | How it is taken | Shared use | Trial weight loss | Self-pay from |
|---|---|---|---|---|---|
 Wegovy | semaglutide | weekly injection or daily tablet | heart risk | 14.9% | $149 per month |
 Rybelsus | semaglutide | daily tablet | heart risk and type 2 diabetes | Not listed | Not listed |
 Mounjaro | tirzepatide | weekly injection | heart risk and type 2 diabetes | Not listed | Not listed |
 Trulicity | dulaglutide | weekly injection | heart risk and type 2 diabetes | Not listed | Not listed |
 Victoza | liraglutide | daily injection | heart risk and type 2 diabetes | Not listed | Not listed |
| Byetta | exenatide | twice-daily injection | type 2 diabetes | Not listed | Not listed |
Sources: TrumpRx, FDA label (DailyMed).