Trulicity for Type 2 Diabetes: A1C Results, Weight
Yes. Trulicity is FDA approved for type 2 diabetes: for adults and children 10 and older with type 2 diabetes, it lowers blood sugar when used with diet and exercise. In AWARD-11, A1C fell 1.77 points on average for people on Trulicity.
- For type 2 diabetes
- FDA approved
- Active ingredient
- dulaglutide
- How it is taken
- weekly injection
- Best result (AWARD-11)
- A1C down 1.77 points
Trulicity in brief
Its half-life is about 5 days. After 5 d, half is gone, and after five half-lives (25 d), about 3% remains.
Reference source: FDA label (DailyMed).
Who qualifies?
| Source | Who qualifies |
|---|---|
| FDA label | For adults and children 10 and older with type 2 diabetes, it lowers blood sugar when used with diet and exercise. |
| FDA label | A lower chance of heart attack, stroke, or heart-related death applies to adults with type 2 diabetes who have several heart risk factors or heart disease. |
Reference source: FDA label (DailyMed).
Type 2 diabetes trial findings
| Trial | Medicine | Who took part | Length | People | Main result |
|---|---|---|---|---|---|
| AWARD-11 | Trulicity | Adults with type 2 diabetes on metformin | 36 weeks | 1,842 | A1C down 1.77 points |
Trial sources: AWARD-11 (PubMed).
Coverage for type 2 diabetes
| What changes | What the label says |
|---|---|
| Low Blood Sugar When Combined with Insulin Secretagogues or Insulin | Combining this medicine with insulin or a sulfonylurea raises the chance of low blood sugar. The doses of those medicines may need lowering. |
| Diabetic retinopathy complications in patients with a history of it | Diabetic eye disease can get worse in people with type 2 diabetes, especially when blood sugar falls fast. Eye checks matter if you already have it. |
| Taken with insulin or sulfonylureas | When this medicine is used with insulin or a sulfonylurea, such as glipizide or glimepiride, the risk of low blood sugar rises. Your doctor may reduce those doses. |
FDA labels say: FDA label info (DailyMed).
These warnings come from the FDA label: FDA label (DailyMed).
Coverage for type 2 diabetes
Medicare Part D may cover these medicines when they are prescribed for diabetes or cardiovascular disease.
Sources: humana.com.
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Alternatives for type 2 diabetes
| Medicine | For type 2 diabetes | How it is taken | Trial result |
|---|---|---|---|
| Trulicity | FDA approved | weekly injection | A1C down 1.77 points |
 Ozempic | FDA approved | weekly injection | Not listed |
 Rybelsus | FDA approved | daily tablet | Not listed |
 Mounjaro | FDA approved | weekly injection | A1C down 2.3 points |
 Victoza | FDA approved | daily injection | Not listed |
| Byetta | FDA approved | twice-daily injection | Not listed |
 Wegovy | Not an approved use | weekly injection or daily tablet | 9.6% weight loss |
 Zepbound | Not an approved use | weekly injection | 14.7% weight loss |
 Foundayo | Not an approved use | daily tablet | 9.6% weight loss |
 Saxenda | Not an approved use | daily injection | 7.4% weight loss |
Sources: FDA label (DailyMed), PubMed.
Questions to ask your prescriber
- Will changes be needed for my other diabetes medicines, particularly insulin or a sulfonylurea?
- How often should I have my eyes checked?
- What A1C level should I target?
Read the full Trulicity DailyMed label.