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GLP-1 Decoder

Triple Agonist Weight Loss Drugs: Status and Trials

Triple agonist weight loss drugs: where it is in development, what the trials show so far, and when it could reach patients.

Retatrutide: a quick overview

Weight loss in its main trial
Retatrutide22.6%

Body weight percentage lost over 80 weeks in people with severe obesity and heart disease (TRIUMPH-3).

How long it stays inside the body
100%50%25%0%06 d12 d18 d24 d30 d50%25%12.5%time after the dose

Half-life is about 6 days: after 6 d, half is gone. At five half-lives (30 d), about 3% is left.

Sources: prnewswire.com, europepmc.org.