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GLP-1 Decoder

How Wegovy Works (and How Fast)

How Wegovy works: a plain explanation, with the facts from the prescribing information.

Active ingredient
semaglutide
Manufacturer
Novo Nordisk
How it is taken
Weekly injection or daily pill
FDA-approved for
Weight loss, Heart risk, MASH liver disease
How Wegovy works: GLP-1 medicines as a pen, a pill and a vial

Wegovy: key facts

How long it remains in your body
100%50%25%0%07 d14 d21 d28 d35 d50%25%12.5%time after the dose

With a half-life of about 1 week, half is gone by 7 d. About 3% remains after five half-lives (35 d).

Weight reduction in the main trial
Wegovy (STEP 1)14.9%Placebo2.4%

For STEP 1, the 68-week result was 14.9% of body weight, compared with 2.4% on placebo.

Costs over time
202520262027$1,349.02$0List priceSelf-pay

Monthly prices in US dollars include the list price plus self-pay offers. Each amount comes from the maker's price page.

Sources: FDA label (DailyMed), healthsystemtracker.org, prnewswire.com 1 2.