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GLP-1 Decoder

How Semaglutide Works (and How Fast)

Semaglutide how it works: a plain explanation, with the facts from the prescribing information.

Active ingredient
semaglutide
Manufacturer
Novo Nordisk
Semaglutide how it works: GLP-1 medicines as a pen, a pill and a vial

Wegovy overview

How long it remains in the body
100%50%25%0%07 d14 d21 d28 d35 d50%25%12.5%time after the dose

About 1 week is the half-life. By 7 d, half remains; after five half-lives, about 3% is left (35 days).

How much weight was lost in the main trial
Wegovy (STEP 1)14.9%Placebo2.4%

Across 68 weeks, STEP 1 reported 14.9% of body weight, compared with 2.4% on placebo.

Prices over time
202520262027$1,349.02$0List priceSelf-pay

In US dollars, monthly prices include a list price and self-pay offers. Each comes from the maker's price page.

Sources: FDA label (DailyMed), healthsystemtracker.org, prnewswire.com 1 2.