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GLP-1 Decoder

Saxenda and Slimming World: Combining Diet Plan and Drug

Yes. Slimming World is not a medicine, so there is nothing to interact. The Saxenda label already pairs the drug with a reduced-calorie diet and more activity, which is what a program like this coaches.

Label names it
No
Drug interaction
None listed
Label pairs it with
Diet and activity

A quick look at Saxenda

How long it stays in your body
100%50%25%0%013 h26 h39 h2.2 d2.7 d50%25%12.5%time after the dose

The half-life is about 13 hours. Half is gone at 13 h, and about 3% remains after five half-lives (2.7 d).

How much weight the main study found people losing
Saxenda (SCALE Obesity and Prediabetes)7.4%Placebo3%

In the SCALE trial on Obesity and Prediabetes, 56 weeks, weight loss was 7.4% of body weight, against 3% for placebo.

Sources: FDA label (DailyMed).

Saxenda in the trials: what it was paired with

The use that was approved, word for word:

“SAXENDA is indicated in combination with a reduced calorie diet and increased physical activity to reduce excess body weight and maintain weight reduction long term”

This comes from the FDA label on DailyMed.

Weight loss in the Saxenda trial

Everyone in these trials also got diet and activity counselling, even those in the placebo group.

Average weight loss in each trial, by dose group
TrialDose groupAverage weight lostPlacebo or comparisonWeeksWho was in it
SCALE Obesity and PrediabetesLiraglutide 3.0 mg daily7.4%3%56Adults without type 2 diabetes who had obesity or were overweight

Source: SCALE Obesity and Prediabetes (FDA label (DailyMed)).