Orforglipron vs Retatrutide: Weight Loss, Side Effects
Orforglipron is FDA approved and sold now; Retatrutide is not FDA approved and is only available in trials. Orforglipron is approved for weight loss.
Foundayo: key facts
The drug's half-life runs 29 to 49 hours. After 39 h, half is gone; five half-lives take 8.1 d, and about 3% remains.
In ATTAIN-1, 72 weeks, the result was 11.1% of body weight, compared with 2.1% on placebo.
Monthly prices in US dollars cover the list price plus self-pay offers, with each figure taken from the price page from the manufacturer.
Sources: FDA label (DailyMed), Eli Lilly, pricinginfo.lilly.com.
Orforglipron and Retatrutide side by side
| Orforglipron | Retatrutide | |
|---|---|---|
| Medicine |  orforglipron | Retatrutide |
| Active ingredient | orforglipron | Not listed |
| Manufacturer | Eli Lilly | Eli Lilly |
| How it is taken | Daily tablet | Not listed |
| Approved for | Weight loss | Not listed |
| First FDA approval | 2026 | Not listed |
| Average weight loss in trials | 11.1% (ATTAIN-1, 72 weeks) | Not listed |
| Most common side effect | Nausea 35% vs 10% on placebo | Not listed |
| List price | $649 per month | Not listed |
| Self-pay from | $149 per month | Not listed |
| Medicare GLP-1 Bridge | $50 per month, eligible Part D | Not listed |
| Weight loss pct | Not listed | 22.6% |
| Weeks | Not listed | 80 weeks |
| Expected | Not listed | BLA submission Q1 2027 |
| Expected approval | Not listed | BLA submission Q1 2027 |
Sources: FDA label, FDA label (DailyMed), pricinginfo.lilly.com, Eli Lilly.
Price and coverage compared
| Medicine | How you pay | Price |
|---|---|---|
| Foundayo | List price before insurance | $649 per month |
| Foundayo | Foundayo Savings Card (insured) | from $25 per month |
| Foundayo | Self-pay: LillyDirect 0.8 mg and 2.5 mg | $149 per month |
| Foundayo | Self-pay: LillyDirect 5.5 mg | $199 per month |
| Foundayo | Self-pay: LillyDirect 9 mg | $299 per month |
| Foundayo | Self-pay 14.5 mg and 17.2 mg doses through LillyDirect (refill within 45 days) | $299 per month |
| Foundayo | Medicare GLP-1 Bridge (Foundayo, eligible Part D) | $50 per month |
Prices checked in November 2026: Eli Lilly, CMS, pricinginfo.lilly.com, foundayo.lilly.com.
Where Retatrutide stands
| Retatrutide | |
|---|---|
| Weight loss pct | 22.6% |
| Weeks | 80 weeks |
| Expected | BLA submission Q1 2027 |
| Expected approval | BLA submission Q1 2027 |
Source: prnewswire.com.