Orforglipron Side Effects: How Common, How Long They Last
In the Foundayo label, nausea is the most common side effect: 35% on 17.2 mg vs 10% on placebo. Next come constipation and diarrhea.
- Most common
- Nausea 35%
- Same on placebo
- 10%
- Stopped because of side effects
- 8%
- Trial group
- Adults with obesity or overweight (weight management)
Foundayo in brief
The half-life ranges from 29 to 49 hours. At 39 h, half is gone; five half-lives (8.1 d) leave about 3%.
In ATTAIN-1, weight loss at 72 weeks was 11.1%, compared with 2.1% in the placebo group.
The maker's price page provides monthly price points in US dollars, including the list price and self-pay offers.
Sources: FDA label (DailyMed), Eli Lilly, pricinginfo.lilly.com.
Orforglipron side effects: label rates vs placebo
According to the FDA label, placebo-controlled trials showed 13 common orforglipron side effects. The last column shows how much more often each side effect appeared than on placebo.
| Side effect | Placebo | Foundayo 5.5 mg | Foundayo 9 mg | Foundayo 17.2 mg | More than placebo, 17.2 mg |
|---|---|---|---|---|---|
| Nausea | 10% | 26% | 34% | 35% | +25 points |
| Constipation | 9% | 20% | 27% | 24% | +15 points |
| Diarrhea | 11% | 21% | 23% | 25% | +14 points |
| Vomiting | 4% | 13% | 21% | 24% | +20 points |
| Dyspepsia | 4% | 12% | 16% | 13% | +9 points |
| Abdominal pain | 7% | 13% | 14% | 14% | +7 points |
| Headache | 7% | 8% | 9% | 9% | +2 points |
| Abdominal distension | 3% | 7% | 9% | 8% | +5 points |
| Fatigue | 4% | 6% | 7% | 9% | +5 points |
| Eructation | 1% | 6% | 8% | 8% | +7 points |
| Gastroesophageal reflux disease | 2% | 6% | 6% | 7% | +5 points |
| Flatulence | 2% | 5% | 6% | 6% | +4 points |
| Hair loss | 2% | 4% | 4% | 5% | +3 points |
Source: FDA label (DailyMed).
Serious warnings, explained simply
- A boxed warning about Thyroid C-cell tumors In rodents, it caused thyroid C-cell tumors; whether it causes them in people is not known. Do not use this medicine if your own or your family's history includes medullary thyroid cancer (MTC), or if you have MEN 2.
- Inflammation of the pancreas The drug can cause inflammation of the pancreas. Get care and stop taking it when severe stomach pain continues, including when the pain sometimes reaches your back.
- Severe stomach and gut reactions. Serious reactions in the stomach and gut. Side effects affecting these areas are common, and they can be severe. This medicine is not recommended for people who have severe gastroparesis.
- Kidney injury from fluid loss. Vomiting or diarrhea can cause fluid loss, which can lead to kidney injury. If you lose a lot of fluid, report it and drink fluids.
- Low blood sugar. A risk of low blood sugar. Using insulin or a sulfonylurea with this medicine makes this problem more likely, so the doses may need to be reduced.
- Allergic reactions may be serious Swelling of your face, lips or throat appeared in reports of serious allergic reactions. If any of these happen, stop the medicine and get help right away.
- Diabetic eye disease getting worse. People who have type 2 diabetes may find diabetic eye disease gets worse, particularly when blood sugar falls quickly. Eye checks matter when you already have diabetic eye disease.
- Gallbladder disease. Gallbladder disease. Gallstones and inflammation of the gallbladder can occur. Report belly pain in the upper right area, fever, or yellow skin or eyes.
- Food entering your lungs while you receive anesthesia or sedation Food may remain in the stomach longer, and this can matter during anesthesia or when you receive deep sedation. Tell the care team before any procedure.
Source: FDA label (DailyMed).
Source: FDA label (DailyMed).