Foundayo for Weight Loss: Results by Dose, Side Effects
Yes. Foundayo is FDA approved for weight loss: for adults with obesity, or overweight adults with a weight-related condition, it supports long-term weight loss and keeping weight off, along with diet and activity. In ATTAIN-1, people on Foundayo lost 11.1% of body weight on average, vs 2.1% on placebo.
- For weight loss
- FDA approved
- Active ingredient
- orforglipron
- How it is taken
- daily tablet
- Best result (ATTAIN-1)
- 11.1% weight loss
Foundayo: key facts
Half is gone after 39 h. The half-life spans 29 to 49 hours, and five half-lives (8.1 d) later about 3% is left.
Over 72 weeks in ATTAIN-1, body weight fell 11.1%, against 2.1% on placebo.
In US dollars, the maker's price page lists monthly prices. These cover the list price along with self-pay offers.
Sources: FDA label (DailyMed), Eli Lilly, pricinginfo.lilly.com.
Who qualifies?
| Who sets the rule | Who qualifies |
|---|---|
| FDA label | For adults with obesity, or overweight adults with a weight-related condition, it supports long-term weight loss and keeping weight off, along with diet and activity. |
| Medicare GLP-1 Bridge | BMI 35 or higher, no condition needed |
| Medicare GLP-1 Bridge | BMI 30 or higher, plus heart failure, uncontrolled blood pressure or CKD 3a+ |
| Medicare GLP-1 Bridge | BMI 27 or higher, plus prediabetes, prior heart attack or stroke, or PAD |
| Typical commercial plan (Aetna policy) | BMI 30 or higher |
| Typical commercial plan (Aetna policy) | BMI 27 or higher with a weight-related condition |
| Typical commercial plan (Aetna policy) | 6 months of a diet and activity program first |
Sources: FDA label (DailyMed), medicare.gov 1 2, aetna.com.
What the weight loss trials found
| Trial | Medicine | Who took part | Length | People | Main result | Comparison |
|---|---|---|---|---|---|---|
| ATTAIN-1 | Foundayo | Adults with obesity or overweight, without diabetes | 72 weeks | 3,127 | 11.1% weight loss | 2.1% on placebo |
Trial source: ATTAIN-1 (FDA label (DailyMed)).
What is different for weight loss?
| What changes | What the label says |
|---|---|
| Acute Pancreatitis | Can cause inflammation of the pancreas. Stop it and get care for stomach pain that is severe and does not go away. The pain sometimes spreads to the back. |
| Acute Gallbladder Disease | Gallstones and gallbladder inflammation can happen. Report pain in the upper right belly, a fever, or yellow skin or eyes. |
These come from the FDA labels: DailyMed FDA label.
These warnings come from the FDA label on DailyMed.
Coverage for weight loss
Medicare Part D does not cover a GLP-1 medicine used only for weight loss.
At $50 per month, Foundayo appears in the Medicare GLP-1 Bridge program, for people who meet the program's rules.
Programs under Medicaid that cover weight-loss GLP-1s usually require approval in advance.
Sources: humana.com, CMS, KFF.
More choices for weight loss
| Medicine | For weight loss | How it is taken | Trial result |
|---|---|---|---|
| Foundayo | FDA approved | daily tablet | 11.1% weight loss |
 Wegovy | FDA approved | weekly injection or daily tablet | 14.9% weight loss |
 Zepbound | FDA approved | weekly injection | 20.9% weight loss |
 Saxenda | FDA approved | daily injection | 7.4% weight loss |
 Ozempic | Not an approved use | weekly injection | Not listed |
 Rybelsus | Not an approved use | daily tablet | Not listed |
 Mounjaro | Not an approved use | weekly injection | Not listed |
 Trulicity | Not an approved use | weekly injection | Not listed |
 Victoza | Not an approved use | daily injection | Not listed |
| Byetta | Not an approved use | twice-daily injection | Not listed |
Sources: FDA label (DailyMed).
Questions to ask your prescriber
- Am I covered by the label's weight rule? Does my plan set a rule of its own?
- Which of the weight-related conditions in my record count?
- In the first year, how much weight should I expect to lose?
- If I stop, what happens then?
See the Foundayo prescribing information on DailyMed for all label details.